biostudies-literatureChen MThe First Affiliated Hospital of Chongqing Medical University 2022 Chongqing Research Innovation Program for Graduate Student (CYB22199)Program for Youth Innovation in Future Medicine, Chongqing Medical UniversityKey Project of Technological Innovation and Application Development of Chongqing Science & Technology BureauChongqing Talent PlanChongqing Medical Key Discipline and Regional Medical Key Discipline DevelopmentProject 0201[2022]No. 144 202325Chongqing Medical Key Discipline and Regional Medical Key Discipline Development ProjectScience Innovation Programs Led by the Academicians in Chongqing8https://www.ebi.ac.uk/biostudies/studies/S-EPMC12849751biostudies-literatureUnknown22(1)<h4>Background</h4>This study aims to investigate the differences in neural network connectivity within the prefrontal cortex (PFC) among elderly individuals with normal cognition (NC), mild cognitive impairment (MCI), and Alzheimer's disease (AD) using functional near-infrared spectroscopy (fNIRS).<h4>Results</h4>Significant differences in functional connectivity (FC) strength were observed between the NC, MCI, and AD groups in several Brodmann areas (BA) pairs, including BA46.L-BA45.R and BA9.L-BA1.L. The most pronounced FC strength differences between the NC and MCI groups occurred at the 2nd -minute mark in BA45.R, while differences between the MCI and AD groups peaked at the 5th-minute mark in BA1.L. Additionally, the NC and MCI groups displayed FC strength differences during the first 2 minutes and first 3 minutes, again with BA45.R being central. FC strength between BA46.L-BA45.R was negatively correlated with Neuropsychiatric Inventory and Clinical Dementia Rating scores.<h4>Conclusions</h4>FC strength in the left dorsolateral PFC, where BA46.L and BA9.L are located, emerged as a key region for cortical dysfunction in cognitive impairment. Moreover, there were differences in FC across levels of cognitive impairment, and significant correlations between differences in FC strength in BA brain regions and cognitive level.Behavioral and brain functions : BBFCorrelation of prefrontal-based resting state functional connectivity with the degree of cognitive impairment in Alzheimer's disease: a functional near-infrared spectroscopy study.PMC128497510201[2022]144 202325zdxk2021052022YSZX-JSX0002CSTB0201[2023] No.160 202412CYYY-BSYJSCXXM-202334W0166cstc2022ycjh-bgzxm0184CSTC2021jscx-gksb-N0020Zhang WYan MGuo YChen MLu YZhong FYu WChen YSong JTian QfalseCorrelation of prefrontal-based resting state functional connectivity with the degree of cognitive impairment in Alzheimer's disease: a functional near-infrared spectroscopy study.<h4>Background</h4>This study aims to investigate the differences in neural network connectivity within the prefrontal cortex (PFC) among elderly individuals with normal cognition (NC), mild cognitive impairment (MCI), and Alzheimer's disease (AD) using functional near-infrared spectroscopy (fNIRS).<h4>Results</h4>Significant differences in functional connectivity (FC) strength were observed between the NC, MCI, and AD groups in several Brodmann areas (BA) pairs, including BA46.L-BA45.R and BA9.L-BA1.L. The most pronounced FC strength differences between the NC and MCI groups occurred at the 2nd -minute mark in BA45.R, while differences between the MCI and AD groups peaked at the 5th-minute mark in BA1.L. Additionally, the NC and MCI groups displayed FC strength differences during the first 2 minutes and first 3 minutes, again with BA45.R being central. FC strength between BA46.L-BA45.R was negatively correlated with Neuropsychiatric Inventory and Clinical Dementia Rating scores.<h4>Conclusions</h4>FC strength in the left dorsolateral PFC, where BA46.L and BA9.L are located, emerged as a key region for cortical dysfunction in cognitive impairment. Moreover, there were differences in FC across levels of cognitive impairment, and significant correlations between differences in FC strength in BA brain regions and cognitive level.2025-01-01T00:00:00Z2025 Dec2026-06-09T07:28:03.357Z2026-06-09T03:12:15.067ZS-EPMC128497514145438510.1186/s12993-025-00316-8