{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yue Y"],"funding":["General Program of National Natural Science Foundation of China","Fundamental Research Funds for the Central Universities","National Key R&D Program of China","Fundamental Research Program of Hubei Province","Self-Innovation Fund of Huazhong Agricultural University","National Natural Science Foundation of China Youth Program","Start-up Foundation of Hubei Hongshan Laboratory"],"pagination":["e13169"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12849889"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(5)"],"pubmed_abstract":["SAGA (Spt-Ada-Gcn5 acetyltransferase) is a highly conserved histone acetyltransferase (HAT) complex in eukaryotes, playing a crucial role in regulating gene transcription during development. The complex consists of two core components: GCN5, the HAT subunit, and ADA2, which primarily functions as an adaptor and enhances the complex HAT activity. Beyond its well-established roles, it is discovered in this work that ADA2 in rice possesses a broadly existing intrinsically disordered region (IDR) that directs the formation of nuclear condensates. Moreover, ADA2 is found to interact with a subunit of ATP-citrate lyase (ACL), an enzyme that produces acetyl-CoA, leading to the formation of a GCN5-ADA2-ACL (GAA) complex. ADA2 promotes the condensation of both GCN5 and ACL in vivo. Within these con"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["ADA2 Forms Nuclear Condensates with GCN5 and ATP-Citrate Lyase (ACL) to Modulate H3K9 Acetylation at Genes Functioning in Rice Meristems."],"pmcid":["PMC12849889"],"funding_grant_id":["2024AFE001","2024YFF1000302","2023hsqd003","32572255","2662025SKPY002","2662025SKPY007","32300462"],"pubmed_authors":["Lai X","Guo J","Guo X","Zhou S","Lu T","Lv S","Abdalla HAM","Liu B","Zhou DX","Zhang R","Yue Y","Zhao Y"],"additional_accession":[]},"is_claimable":false,"name":"ADA2 Forms Nuclear Condensates with GCN5 and ATP-Citrate Lyase (ACL) to Modulate H3K9 Acetylation at Genes Functioning in Rice Meristems.","description":"SAGA (Spt-Ada-Gcn5 acetyltransferase) is a highly conserved histone acetyltransferase (HAT) complex in eukaryotes, playing a crucial role in regulating gene transcription during development. The complex consists of two core components: GCN5, the HAT subunit, and ADA2, which primarily functions as an adaptor and enhances the complex HAT activity. Beyond its well-established roles, it is discovered in this work that ADA2 in rice possesses a broadly existing intrinsically disordered region (IDR) that directs the formation of nuclear condensates. Moreover, ADA2 is found to interact with a subunit of ATP-citrate lyase (ACL), an enzyme that produces acetyl-CoA, leading to the formation of a GCN5-ADA2-ACL (GAA) complex. ADA2 promotes the condensation of both GCN5 and ACL in vivo. Within these con","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-13T05:23:51.519Z","creation":"2026-06-13T03:08:46.653Z"},"accession":"S-EPMC12849889","cross_references":{"pubmed":["41221643"],"doi":["10.1002/advs.202513169"]}}