{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["39(1)"],"submitter":["Leung FW"],"pubmed_abstract":["<h4>Background</h4>Interval cancers are linked to a low adenoma detection rate (ADR), prompting calls for benchmark-guided ADR performance improvement. Although water exchange and a straight cap (CAP) have been reported to independently improve ADR, the effects of Daisycuff<sup>™</sup> and Endocuff Vision<sup>®</sup> remained unknown. We hypothesized that selected cap(s) could increase ADR and related water exchange outcomes.<h4>Methods</h4>Subjects were randomized to No cap, or CAP, Daisycuff<sup>™</sup> and Endocuff Vision<sup>®</sup> at 7, 5 and 2 sites. The primary outcome was ADR. Outcomes were compared for No cap vs. the above randomized caps.<h4>Results</h4>Demographic and historic data revealed adequate randomization. Despite variations in site-specific pretrial ADR, the aggregated"],"journal":["Annals of gastroenterology"],"pagination":["104-113"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12850690"],"repository":["biostudies-literature"],"pubmed_title":["A prospective international multisite randomized controlled trial of water exchange with and without distal cap(s) in adenoma detection."],"pmcid":["PMC12850690"],"pubmed_authors":["Elashoff D","Jia H","Leung JW","Tsui YN","Zhang L","Leung FW","Friedland S","Mura D","Shaikh A","Cheung R","Jacob N","Chen Y","Sul J","Pan JY","Wilhalme H","Cheng CH","Saha A","Wong RJ","Hsieh YH","Pan Y","Gallittu P","Chen L","Cadoni S","Jamgotchian N","Lee BP","Kuo YL","Tseng CW","Dixit V","Yen AW","Quan SY","Cheng CL"],"additional_accession":[]},"is_claimable":false,"name":"A prospective international multisite randomized controlled trial of water exchange with and without distal cap(s) in adenoma detection.","description":"<h4>Background</h4>Interval cancers are linked to a low adenoma detection rate (ADR), prompting calls for benchmark-guided ADR performance improvement. Although water exchange and a straight cap (CAP) have been reported to independently improve ADR, the effects of Daisycuff<sup>™</sup> and Endocuff Vision<sup>®</sup> remained unknown. We hypothesized that selected cap(s) could increase ADR and related water exchange outcomes.<h4>Methods</h4>Subjects were randomized to No cap, or CAP, Daisycuff<sup>™</sup> and Endocuff Vision<sup>®</sup> at 7, 5 and 2 sites. The primary outcome was ADR. Outcomes were compared for No cap vs. the above randomized caps.<h4>Results</h4>Demographic and historic data revealed adequate randomization. Despite variations in site-specific pretrial ADR, the aggregated","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan-Feb","modification":"2026-06-16T07:12:03.243Z","creation":"2026-06-16T03:09:48.316Z"},"accession":"S-EPMC12850690","cross_references":{"pubmed":["41612984"],"doi":["10.20524/aog.2026.1020"]}}