biostudies-literatureUnknown39(1)Amato SInflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, compromises both physical and psychological health. High levels of stress, anxiety, and depression are common yet often overlooked, negatively impacting treatment adherence and self-care. This review examines how psychological factors influence self-care behaviors in IBD and explores strategies to improve disease management. Following PRISMA guidelines and registered on PROSPERO (CRD42024575631), this systematic review applied the PICO model to identify studies involving IBD patients, self-care interventions, and outcomes related to depression, anxiety and stress. A comprehensive search was conducted in PubMed, CINAHL, Web of Science, Scopus, Cochrane Library, APA PsycInfo and Google Scholar (October-DecembAnnals of gastroenterology11-22https://www.ebi.ac.uk/biostudies/studies/S-EPMC12850693biostudies-literatureThe impact of depression, anxiety and stress on self-care in inflammatory bowel disease: a systematic review.PMC12850693Orgiana NAmato SD'Onofrio AMCascio ALSguanci MIannuzzi FScaldaferri FCamardese GCocco MNapolitano DfalseThe impact of depression, anxiety and stress on self-care in inflammatory bowel disease: a systematic review.Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, compromises both physical and psychological health. High levels of stress, anxiety, and depression are common yet often overlooked, negatively impacting treatment adherence and self-care. This review examines how psychological factors influence self-care behaviors in IBD and explores strategies to improve disease management. Following PRISMA guidelines and registered on PROSPERO (CRD42024575631), this systematic review applied the PICO model to identify studies involving IBD patients, self-care interventions, and outcomes related to depression, anxiety and stress. A comprehensive search was conducted in PubMed, CINAHL, Web of Science, Scopus, Cochrane Library, APA PsycInfo and Google Scholar (October-Decemb2026-01-01T00:00:00Z2026 Jan-Feb2026-06-16T07:13:58.693Z2026-06-16T03:10:04.542ZS-EPMC128506934161298710.20524/aog.2026.1024