{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Amer MM"],"funding":["Lithuanian State Studies Foundation","EPSRC","Engineering and Physical Sciences Research Council"],"pagination":["e21374"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12850996"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["65(5)"],"pubmed_abstract":["An asymmetric intramolecular hydride shift reaction has been developed that is catalyzed by Al Lewis acids in conjunction with a chiral BINOL-derived ligand. Racemic THP substrates are transformed into cyclohexene products via a prochiral intermediate ring opened enone; which then undergoes a key 1,5-hydride shift reaction. This reaction is operationally simple, works well on a gram scale, and the desired products are formed with very high enantioselectivity (up to >98:2 e.r.). Importantly, the cyclohexene products contain functionality that can be easily derivatized and this is exemplified in the paper. Finally, a model is presented for the enantioselective hydride shift that is based on previous DFT studies."],"journal":["Angewandte Chemie (International ed. in English)"],"pubmed_title":["Asymmetric Hydride Shift Reactions Catalyzed by Chiral Aluminium Complexes."],"pmcid":["PMC12850996"],"funding_grant_id":["EP/W02246X/1","EP/V028995/1"],"pubmed_authors":["Donohoe TJ","Hou J","Mazeikaite A","Wang J","Amer MM"],"additional_accession":[]},"is_claimable":false,"name":"Asymmetric Hydride Shift Reactions Catalyzed by Chiral Aluminium Complexes.","description":"An asymmetric intramolecular hydride shift reaction has been developed that is catalyzed by Al Lewis acids in conjunction with a chiral BINOL-derived ligand. Racemic THP substrates are transformed into cyclohexene products via a prochiral intermediate ring opened enone; which then undergoes a key 1,5-hydride shift reaction. This reaction is operationally simple, works well on a gram scale, and the desired products are formed with very high enantioselectivity (up to >98:2 e.r.). Importantly, the cyclohexene products contain functionality that can be easily derivatized and this is exemplified in the paper. Finally, a model is presented for the enantioselective hydride shift that is based on previous DFT studies.","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-10T09:01:32.924Z","creation":"2026-06-10T03:11:53.194Z"},"accession":"S-EPMC12850996","cross_references":{"pubmed":["41410305"],"doi":["10.1002/anie.202521374"]}}