biostudies-literatureFan SU.S. Department of EnergyNational Natural Science Foundation of ChinaNational Institutes of HealthNIGMS NIH HHSShanghai Jiao Tong Universityeady0545https://www.ebi.ac.uk/biostudies/studies/S-EPMC12851029biostudies-literatureUnknown12(5)Surface-enhanced coherent anti-Stokes Raman scattering (SECARS) is believed to increase the signal intensity and sensitivity by combining the localized surface plasmon resonance and coherent Raman enhancement. However, the realization of SECARS is more complex than for surface-enhanced Raman scattering (SERS) and remains challenging. Unlike SERS, the nonlinear CARS process requires the coherent interaction of three distinct fields. The interactions between the electric fields and nanoparticle (NP) morphology for single-particle SECARS remain unexplored, and the underlying mechanisms generating the SECARS signal are not fully understood. Here, 27 distinct NPs were synthesized and screened using a CARS microscope. Among them, only star-core core-satellite NPs show single-particle SECARS signScience advancesSingle-particle surface-enhanced coherent anti-Stokes Raman scattering: Nanoparticle design and mechanism.PMC12851029FWP 79928YG2024LC09R01 GM10998882272054Wang CFShoup DNLuo ZHe JSmith AESchultz ZDScarpitti BTFan SLiang ESchorr HCCheng RCheng JXLin HYe JfalseSingle-particle surface-enhanced coherent anti-Stokes Raman scattering: Nanoparticle design and mechanism.Surface-enhanced coherent anti-Stokes Raman scattering (SECARS) is believed to increase the signal intensity and sensitivity by combining the localized surface plasmon resonance and coherent Raman enhancement. However, the realization of SECARS is more complex than for surface-enhanced Raman scattering (SERS) and remains challenging. Unlike SERS, the nonlinear CARS process requires the coherent interaction of three distinct fields. The interactions between the electric fields and nanoparticle (NP) morphology for single-particle SECARS remain unexplored, and the underlying mechanisms generating the SECARS signal are not fully understood. Here, 27 distinct NPs were synthesized and screened using a CARS microscope. Among them, only star-core core-satellite NPs show single-particle SECARS sign2026-01-01T00:00:00Z2026 Jan2026-06-14T06:05:07.941Z2026-06-14T03:17:17.037ZS-EPMC128510294160447410.1126/sciadv.ady0545