biostudies-literatureUnknown105(4)Bokhari SFH<h4>Background</h4>Atrial fibrillation (AF) remains the most common sustained cardiac arrhythmia. Pulsed field ablation (PFA) and cryoablation (CA) aim to isolate pulmonary veins and prevent AF recurrence. This meta-analysis aims to provide a comprehensive comparison of PFA and CA in treatment of AF in context of efficacy, procedural characteristics, and safety profiles.<h4>Methods</h4>A comprehensive literature search of databases (PubMed, Cochrane Library, Science Direct and Google Scholar) was conducted from their inception to September 2024. Statistical analyses were conducted using Cochrane's RevMan 5.4 software.<h4>Results</h4>Twenty studies (n = 4638; PFA = 2172, CA = 3033) were included in this meta-analysis. Regarding efficacy outcomes, PFA significantly reduced AF recurrence (oddMedicinee47353https://www.ebi.ac.uk/biostudies/studies/S-EPMC12851682biostudies-literatureSafety and efficacy of pulsed field ablation versus cryoablation for atrial fibrillation: A comprehensive meta-analysis.PMC12851682Asif AWaleed MMubashir MMSana HBakht DIqbal AAli KQureshi MAAli MKBHassan AAwais MNBokhari SFHAmir MfalseSafety and efficacy of pulsed field ablation versus cryoablation for atrial fibrillation: A comprehensive meta-analysis.<h4>Background</h4>Atrial fibrillation (AF) remains the most common sustained cardiac arrhythmia. Pulsed field ablation (PFA) and cryoablation (CA) aim to isolate pulmonary veins and prevent AF recurrence. This meta-analysis aims to provide a comprehensive comparison of PFA and CA in treatment of AF in context of efficacy, procedural characteristics, and safety profiles.<h4>Methods</h4>A comprehensive literature search of databases (PubMed, Cochrane Library, Science Direct and Google Scholar) was conducted from their inception to September 2024. Statistical analyses were conducted using Cochrane's RevMan 5.4 software.<h4>Results</h4>Twenty studies (n = 4638; PFA = 2172, CA = 3033) were included in this meta-analysis. Regarding efficacy outcomes, PFA significantly reduced AF recurrence (odd2026-01-01T00:00:00Z2026 Jan2026-06-14T05:45:29.563Z2026-06-14T03:08:47.597ZS-EPMC128516824157854310.1097/MD.0000000000047353