{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bromage TG"],"funding":["NCRR NIH HHS","NIH HHS"],"pagination":["1197-1205"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12851940"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["649(8099)"],"pubmed_abstract":["The science of metabolic profiling exploits chemical compound byproducts of metabolism called metabolites<sup>1</sup> that explain internal biological functions, physiological health and disease, and provide evidence of external influences specific to an organism's habitat. Here we assess palaeometabolomes from fossilized mammalian hard tissues as a molecular ecological strategy to provide evidence of an ancient organism's relationship with its environment. From eastern, central and southern African Plio-Pleistocene localities of palaeoanthropological significance, we study six fossils from Olduvai Gorge, Tanzania, one from the Chiwondo Beds, Malawi, and one from Makapansgat, South Africa. We perform endogeneity assessments by analysing palaeometabolomes of palaeosols and the effects of ow"],"journal":["Nature"],"pubmed_title":["Palaeometabolomes yield biological and ecological profiles at early human sites."],"pmcid":["PMC12851940"],"funding_grant_id":["S10 OD026989","S10 OD023659","S10 RR027990"],"pubmed_authors":["Denys C","Rabieh S","De Jesus CL","Yakar S","Neubert TA","Kullmer O","Hu B","Souron A","Bromage TG","Buss DJ","Kubat J","Sandrock O","Schrenk F","Reznikov N","Poudel SB","Erdjument-Bromage H","Ittah E","Ashley GM","McKee MD"],"additional_accession":[]},"is_claimable":false,"name":"Palaeometabolomes yield biological and ecological profiles at early human sites.","description":"The science of metabolic profiling exploits chemical compound byproducts of metabolism called metabolites<sup>1</sup> that explain internal biological functions, physiological health and disease, and provide evidence of external influences specific to an organism's habitat. Here we assess palaeometabolomes from fossilized mammalian hard tissues as a molecular ecological strategy to provide evidence of an ancient organism's relationship with its environment. From eastern, central and southern African Plio-Pleistocene localities of palaeoanthropological significance, we study six fossils from Olduvai Gorge, Tanzania, one from the Chiwondo Beds, Malawi, and one from Makapansgat, South Africa. We perform endogeneity assessments by analysing palaeometabolomes of palaeosols and the effects of ow","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-12T10:16:52.917Z","creation":"2026-06-12T03:12:05.613Z"},"accession":"S-EPMC12851940","cross_references":{"pubmed":["41407854"],"doi":["10.1038/s41586-025-09843-w"]}}