biostudies-literatureUnknown41(3)Plonsky Toder MTechnion - Israel Institute of Technology<h4>Background</h4>Takayasu arteritis (TAK) is a granulomatous large-vessel vasculitis typically affecting young adult females. Pediatric cases are rare, and infantile onset is exceptional. Management relies on immunosuppression, with surgery reserved for severe complications.<h4>Case report</h4>We describe a now 5.5-year-old boy diagnosed with TAK at six months of age, presenting with hypertensive encephalopathy and kidney dysfunction. Despite treatment with corticosteroids and anti-TNFα, his kidney function deteriorated, leading to kidney failure and dialysis. At nearly three years of age, he underwent abdominal aorto-aortic bypass and bilateral nephrectomy due to progressive vascular narrowing and refractory hypertension. At age four, he successfully received a deceased-donor kidney traPediatric nephrology (Berlin, Germany)873-881https://www.ebi.ac.uk/biostudies/studies/S-EPMC12852304biostudies-literatureNavigating complex clinical decisions: kidney transplantation following abdominal aorto-aortic bypass in infantile Takayasu arteritis.PMC12852304Plonsky Toder MMagen DTibi RSteinberg RKarram TEisenstein IColeman DPollack SLibinson-Zebegret IHoffman AYakubov RfalseNavigating complex clinical decisions: kidney transplantation following abdominal aorto-aortic bypass in infantile Takayasu arteritis.<h4>Background</h4>Takayasu arteritis (TAK) is a granulomatous large-vessel vasculitis typically affecting young adult females. Pediatric cases are rare, and infantile onset is exceptional. Management relies on immunosuppression, with surgery reserved for severe complications.<h4>Case report</h4>We describe a now 5.5-year-old boy diagnosed with TAK at six months of age, presenting with hypertensive encephalopathy and kidney dysfunction. Despite treatment with corticosteroids and anti-TNFα, his kidney function deteriorated, leading to kidney failure and dialysis. At nearly three years of age, he underwent abdominal aorto-aortic bypass and bilateral nephrectomy due to progressive vascular narrowing and refractory hypertension. At age four, he successfully received a deceased-donor kidney tra2026-01-01T00:00:00Z2026 Mar2026-06-16T03:16:01.752Z2026-06-16T03:09:42.138ZS-EPMC128523044093250210.1007/s00467-025-06932-w