{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Peng Y"],"funding":["National Natural Science Foundation of China","National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["1078"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12852848"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["Inspired by the non-transmembrane transfer of mitochondria in cell-to-cell communications, herein, we report an original exploration to accelerate mitochondrial intercellular transport, and its application to exogenous cargo delivery. We discover that deliberate PINK1-targeted mitophagy downregulation elevates mitochondrial transit capacity via multifaceted drivers-morphological adaptation, metabolic reprogramming, and respiratory enhancement. Capitalizing on this, we engineer high-speed mitochondrial vehicles for photosensitizer hitchhiking, with spatiotemporal tracking elucidating its dynamic intercellular transit and physiological impacts. Through mitochondria's communication network-tunneling nanotubes (TNTs), the mitochondria-photosensitizer cotransporter achieves reinforced intercell"],"journal":["Nature communications"],"pubmed_title":["Leveraging engineered mitochondria through intercellular communication network for accelerated transport and delivery."],"pmcid":["PMC12852848"],"funding_grant_id":["82373806"],"pubmed_authors":["Peng Y","Li X","Yang Z","Yang Y","Li J","Qi X","Du Y","Zhou Y","Lin M","Gao D"],"additional_accession":[]},"is_claimable":false,"name":"Leveraging engineered mitochondria through intercellular communication network for accelerated transport and delivery.","description":"Inspired by the non-transmembrane transfer of mitochondria in cell-to-cell communications, herein, we report an original exploration to accelerate mitochondrial intercellular transport, and its application to exogenous cargo delivery. We discover that deliberate PINK1-targeted mitophagy downregulation elevates mitochondrial transit capacity via multifaceted drivers-morphological adaptation, metabolic reprogramming, and respiratory enhancement. Capitalizing on this, we engineer high-speed mitochondrial vehicles for photosensitizer hitchhiking, with spatiotemporal tracking elucidating its dynamic intercellular transit and physiological impacts. Through mitochondria's communication network-tunneling nanotubes (TNTs), the mitochondria-photosensitizer cotransporter achieves reinforced intercell","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-16T07:18:10.94Z","creation":"2026-06-16T03:10:10.611Z"},"accession":"S-EPMC12852848","cross_references":{"pubmed":["41436474"],"doi":["10.1038/s41467-025-67837-8"]}}