biostudies-literatureUnknown13(1)Fujita M<h4>Aim</h4>To reassess the efficacy of hyperbaric oxygen (HBO) therapy for acute carbon monoxide (CO) poisoning through a systematic review and meta-analysis, including a subgroup analysis of treatment pressures exceeding 2.5 atm absolute (ATA).<h4>Methods</h4>We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) evaluating HBO therapy for acute CO poisoning. A literature search was performed in MEDLINE, CENTRAL, and Ichushi-Web databases, focusing on RCTs published up to June 2024. Only adult patients (≥ 18 years) were included, and studies were screened following PRISMA guidelines. Data extraction and quality assessment were conducted by two independent reviewers using the Cochrane risk of bias tool and the GRADE approach. Statistical analysis used a Acute medicine & surgerye70114https://www.ebi.ac.uk/biostudies/studies/S-EPMC12853008biostudies-literatureEvaluating the Efficacy of Hyperbaric Oxygen Therapy for Acute Carbon Monoxide Poisoning: A Systematic Review and Meta-Analysis.PMC12853008Ajimi YKobata HChihara NNakamoto HKurihara MIwase MJapan Resuscitation Council (JRC) Neuroresuscitation Task Force and the Guidelines Editorial CommitteeYoshimura HTsuruta RNagayama MFujita MYokobori SMoriya TTogawa MTodani MKawamoto MSamkamoto TWakasugi MUchida HYatabe TTodo KNakae RKondo YYamagami HHoshiyama EAraki MYang SfalseEvaluating the Efficacy of Hyperbaric Oxygen Therapy for Acute Carbon Monoxide Poisoning: A Systematic Review and Meta-Analysis.<h4>Aim</h4>To reassess the efficacy of hyperbaric oxygen (HBO) therapy for acute carbon monoxide (CO) poisoning through a systematic review and meta-analysis, including a subgroup analysis of treatment pressures exceeding 2.5 atm absolute (ATA).<h4>Methods</h4>We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) evaluating HBO therapy for acute CO poisoning. A literature search was performed in MEDLINE, CENTRAL, and Ichushi-Web databases, focusing on RCTs published up to June 2024. Only adult patients (≥ 18 years) were included, and studies were screened following PRISMA guidelines. Data extraction and quality assessment were conducted by two independent reviewers using the Cochrane risk of bias tool and the GRADE approach. Statistical analysis used a 2026-01-01T00:00:00Z2026 Jan-Dec2026-06-19T03:08:15.853Z2026-06-19T03:06:43.938ZS-EPMC128530084162462710.1002/ams2.70114