{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["61(2)"],"submitter":["Jordan J"],"pubmed_abstract":["Proton-transfer-reaction-mass spectrometry (PTR-MS) provides real-time analysis of volatile organic compounds (VOCs) relevant to atmospheric research, food and flavor characterization, industrial process control, and medical applications. However, PTR-MS is inherently limited in its ability to resolve isomers of molecules with the same mass-to-charge ratio (m/z). To address this selectivity constraint, we coupled a time-of-flight (TOF) based PTR-MS setup with a \"Structures for Lossless Ion Manipulations Ion Mobility Spectrometry\" (SLIM IMS) module. The integration of SLIM IMS introduces an additional separation dimension without compromising the real-time capability of PTR-MS. A custom designed SLIM device enabled efficient confinement and transmission of low mass ions (m/z < 300), which a"],"journal":["Journal of mass spectrometry : JMS"],"pagination":["e70031"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12853077"],"repository":["biostudies-literature"],"pubmed_title":["Selectivity Beyond Mass: Real-Time Isomer Separation Using SLIM IMS Coupled to PTR-MS."],"pmcid":["PMC12853077"],"pubmed_authors":["Sulzer P","Jordan A","Hanel G","Beyer MK","Jordan J","Fugenschuh T","Lindinger C"],"additional_accession":[]},"is_claimable":false,"name":"Selectivity Beyond Mass: Real-Time Isomer Separation Using SLIM IMS Coupled to PTR-MS.","description":"Proton-transfer-reaction-mass spectrometry (PTR-MS) provides real-time analysis of volatile organic compounds (VOCs) relevant to atmospheric research, food and flavor characterization, industrial process control, and medical applications. However, PTR-MS is inherently limited in its ability to resolve isomers of molecules with the same mass-to-charge ratio (m/z). To address this selectivity constraint, we coupled a time-of-flight (TOF) based PTR-MS setup with a \"Structures for Lossless Ion Manipulations Ion Mobility Spectrometry\" (SLIM IMS) module. The integration of SLIM IMS introduces an additional separation dimension without compromising the real-time capability of PTR-MS. A custom designed SLIM device enabled efficient confinement and transmission of low mass ions (m/z < 300), which a","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-06-16T07:12:30.121Z","creation":"2026-06-16T03:09:55.453Z"},"accession":"S-EPMC12853077","cross_references":{"pubmed":["41607201"],"doi":["10.1002/jms.70031"]}}