{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Xiang P"],"pubmed_abstract":["<i>N</i>-Fluorosulfamoyl pyridinium salts have been ingeniously developed as redox-active precursors for generating fluorosulfamoyl radicals. However, the ubiquitous pyridine scaffold within these compounds, commonplace in numerous pharmaceuticals, has remained being wasted in reported methods only as a radical leaving group. This underutilization presents both a significant challenge and an exciting opportunity for further research in synthetic, medicinal, and materials chemistry. Herein, <i>N</i>-fluorosulfamoyl pyridinium salts were employed as bifunctional reagents to achieve remote and selective C-H functionalization of pyridines through a radical relay process that enables polarity reversal of radical intermediates. By employing ZnIn<sub>2</sub>S<sub>4</sub> as a heterogeneous photoc"],"journal":["Chemical science"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12853103"],"repository":["biostudies-literature"],"pubmed_title":["Heterogeneous photocatalytic C4 remote fluorosulfonamidation of pyridines."],"pmcid":["PMC12853103"],"pubmed_authors":["Xiang P","Yu B","Zhang Y","Qu L","Chen X","Li K","Sun K"],"additional_accession":[]},"is_claimable":false,"name":"Heterogeneous photocatalytic C4 remote fluorosulfonamidation of pyridines.","description":"<i>N</i>-Fluorosulfamoyl pyridinium salts have been ingeniously developed as redox-active precursors for generating fluorosulfamoyl radicals. However, the ubiquitous pyridine scaffold within these compounds, commonplace in numerous pharmaceuticals, has remained being wasted in reported methods only as a radical leaving group. This underutilization presents both a significant challenge and an exciting opportunity for further research in synthetic, medicinal, and materials chemistry. Herein, <i>N</i>-fluorosulfamoyl pyridinium salts were employed as bifunctional reagents to achieve remote and selective C-H functionalization of pyridines through a radical relay process that enables polarity reversal of radical intermediates. By employing ZnIn<sub>2</sub>S<sub>4</sub> as a heterogeneous photoc","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-19T04:56:47.82Z","creation":"2026-06-19T03:06:40.381Z"},"accession":"S-EPMC12853103","cross_references":{"pubmed":["41626187"],"doi":["10.1039/d5sc08495d"]}}