biostudies-literatureUnknownXiang P<i>N</i>-Fluorosulfamoyl pyridinium salts have been ingeniously developed as redox-active precursors for generating fluorosulfamoyl radicals. However, the ubiquitous pyridine scaffold within these compounds, commonplace in numerous pharmaceuticals, has remained being wasted in reported methods only as a radical leaving group. This underutilization presents both a significant challenge and an exciting opportunity for further research in synthetic, medicinal, and materials chemistry. Herein, <i>N</i>-fluorosulfamoyl pyridinium salts were employed as bifunctional reagents to achieve remote and selective C-H functionalization of pyridines through a radical relay process that enables polarity reversal of radical intermediates. By employing ZnIn₂S₄ as a heterogeneous photocChemical sciencehttps://www.ebi.ac.uk/biostudies/studies/S-EPMC12853103biostudies-literatureHeterogeneous photocatalytic C4 remote fluorosulfonamidation of pyridines.PMC12853103Xiang PYu BZhang YQu LChen XLi KSun KfalseHeterogeneous photocatalytic C4 remote fluorosulfonamidation of pyridines.<i>N</i>-Fluorosulfamoyl pyridinium salts have been ingeniously developed as redox-active precursors for generating fluorosulfamoyl radicals. However, the ubiquitous pyridine scaffold within these compounds, commonplace in numerous pharmaceuticals, has remained being wasted in reported methods only as a radical leaving group. This underutilization presents both a significant challenge and an exciting opportunity for further research in synthetic, medicinal, and materials chemistry. Herein, <i>N</i>-fluorosulfamoyl pyridinium salts were employed as bifunctional reagents to achieve remote and selective C-H functionalization of pyridines through a radical relay process that enables polarity reversal of radical intermediates. By employing ZnIn₂S₄ as a heterogeneous photoc2026-01-01T00:00:00Z2026 Jan2026-06-19T04:56:47.82Z2026-06-19T03:06:40.381ZS-EPMC128531034162618710.1039/d5sc08495d