{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(1)"],"submitter":["Dorji T"],"pubmed_abstract":["<h4>Background</h4>The proportion of multidrug-resistant tuberculosis (MDR-TB) cases is increasing in Bhutan. We conducted the first retrospective genomic-epidemiological study to provide insights into the population structure, resistance patterns, and recent transmission in Bhutan.<h4>Methods</h4>Whole genome sequencing was performed on randomly selected drug-resistant (DR-TB) and drug-sensitive TB (DS-TB) isolates from Bhutan, collected between 2018 and 2022 at the Microbiological Diagnostic Unit Public Health Laboratory in Melbourne, Australia. Bioinformatic analysis was performed to identify drug-resistance mutations and genomic clustering of cases.<h4>Results</h4>Approximately 40% of DR-TB and 2.5% of DS-TB were sequenced each year. Of the 203 sequences that passed the quality control"],"journal":["Open forum infectious diseases"],"pagination":["ofaf802"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12853382"],"repository":["biostudies-literature"],"pubmed_title":["Extensive Endemic Transmission of Multidrug-Resistant &lt;i&gt;Mycobacterium tuberculosis&lt;/i&gt; in Bhutan: A Retrospective Genomic-Epidemiological Study."],"pmcid":["PMC12853382"],"pubmed_authors":["Lhaden P","Jamtsho T","Wirth W","Denholm JT","Sait M","Andersson P","Adhikari L","Dorji T","Bhujel P","Sherry NL","Stinear TP","Wangchuk S","Howden BP","Tshering K","Horan K"],"additional_accession":[]},"is_claimable":false,"name":"Extensive Endemic Transmission of Multidrug-Resistant &lt;i&gt;Mycobacterium tuberculosis&lt;/i&gt; in Bhutan: A Retrospective Genomic-Epidemiological Study.","description":"<h4>Background</h4>The proportion of multidrug-resistant tuberculosis (MDR-TB) cases is increasing in Bhutan. We conducted the first retrospective genomic-epidemiological study to provide insights into the population structure, resistance patterns, and recent transmission in Bhutan.<h4>Methods</h4>Whole genome sequencing was performed on randomly selected drug-resistant (DR-TB) and drug-sensitive TB (DS-TB) isolates from Bhutan, collected between 2018 and 2022 at the Microbiological Diagnostic Unit Public Health Laboratory in Melbourne, Australia. Bioinformatic analysis was performed to identify drug-resistance mutations and genomic clustering of cases.<h4>Results</h4>Approximately 40% of DR-TB and 2.5% of DS-TB were sequenced each year. Of the 203 sequences that passed the quality control","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-19T03:17:25.687Z","creation":"2026-06-19T03:07:11.27Z"},"accession":"S-EPMC12853382","cross_references":{"pubmed":["41626299"],"doi":["10.1093/ofid/ofaf802"]}}