{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang S"],"funding":["Medical Science and Technology Project of Zhejiang Province","Zhejiang Provincial Postdoctoral Science Foundation","Natural Science Foundation of Hubei Province, China","Hubei Provincial Science and Technology Plan Project","Foundation for Innovative Research Groups of Hubei Province","Hubei University of Chinese Medicine 2024 Annual Science and Technology Innovation Project"],"pagination":["93"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12853929"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["The pharmacological activities of traditional herbal medicine-derived carbon dots (THM-CDs) render them highly promising for applications in biomedicine. However, the interactions between THM-CDs and intracellular proteins have yet to be fully elucidated. Herein, inspired by the traditional vinegar-processing of Artemisia argyi (A. argyi), acetic acid-treated Artemisia argyi-derived carbon dots (AA-CDs) demonstrate excellent resistance to iron death via efficient ROS scavenging and Fe<sup>2+</sup> chelating. Notably, multi-omics analysis uncovers a novel whereby AA-CDs directly target and stabilize heat shock protein A5 (HSPA5), thus preventing the degradation of glutathione peroxidase 4 (GPX4), a pivotal negative regulator of ferroptosis. Emerging evidence indicates that ferroptosis plays"],"journal":["Journal of nanobiotechnology"],"pubmed_title":["Artemisia-derived carbon dots with excellent pharmacological activities and ROS scavenging for osteoarthritis treatment."],"pmcid":["PMC12853929"],"funding_grant_id":["2026784378","2025AFD483","ZY2025J001","390298","2024KJCX004","2025BCB043"],"pubmed_authors":["Fan F","Wu J","Xu K","Liu M","Wang S","Wang C","Hu X","Chen G","Wei K"],"additional_accession":[]},"is_claimable":false,"name":"Artemisia-derived carbon dots with excellent pharmacological activities and ROS scavenging for osteoarthritis treatment.","description":"The pharmacological activities of traditional herbal medicine-derived carbon dots (THM-CDs) render them highly promising for applications in biomedicine. However, the interactions between THM-CDs and intracellular proteins have yet to be fully elucidated. Herein, inspired by the traditional vinegar-processing of Artemisia argyi (A. argyi), acetic acid-treated Artemisia argyi-derived carbon dots (AA-CDs) demonstrate excellent resistance to iron death via efficient ROS scavenging and Fe<sup>2+</sup> chelating. Notably, multi-omics analysis uncovers a novel whereby AA-CDs directly target and stabilize heat shock protein A5 (HSPA5), thus preventing the degradation of glutathione peroxidase 4 (GPX4), a pivotal negative regulator of ferroptosis. Emerging evidence indicates that ferroptosis plays","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-13T06:31:06.172Z","creation":"2026-06-13T03:12:49.192Z"},"accession":"S-EPMC12853929","cross_references":{"pubmed":["41559762"],"doi":["10.1186/s12951-026-04046-5"]}}