{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(3)"],"submitter":["Demirkıran O"],"pubmed_abstract":["The red alga genus <i>Laurencia</i> (Rhodomelaceae) is a prolific source of halogenated secondary metabolites, particularly sesquiterpenes with diverse carbon skeletons and significant biological activities. In this study, four new perforane-type sesquiterpenes (<b>1</b>-<b>4</b>), including two halogenated and two nonhalogenated compounds, were isolated from <i>Laurencia obtusa</i> (Hudson) J. V. Lamouroux. Their chemical structures were elucidated using comprehensive spectroscopic techniques, including 1D- and 2D-NMR, and LC-HRMS. The cytotoxic potential of the isolated compounds was evaluated against human lung adenocarcinoma (A549) cells, revealing notable antiproliferative effects. To explore the molecular basis of their activity, molecular docking and molecular dynamics simulations w"],"journal":["ACS omega"],"pagination":["4135-4154"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12854617"],"repository":["biostudies-literature"],"pubmed_title":["Four New Perforane-Type Sesquiterpenes from &lt;i&gt;Laurencia obtusa&lt;/i&gt; (Hudson) J.V. Lamouroux as Potent Lung Cancer Inhibitors: Isolation, Structure Elucidation, Cytotoxicity, Molecular Docking, Dynamics, and ADME Studies."],"pmcid":["PMC12854617"],"pubmed_authors":["Topcu G","Senol H","Okudan ES","Alim Toraman GO","Erol E","Elci Y","Coskun E","Demirkıran O"],"additional_accession":[]},"is_claimable":false,"name":"Four New Perforane-Type Sesquiterpenes from &lt;i&gt;Laurencia obtusa&lt;/i&gt; (Hudson) J.V. Lamouroux as Potent Lung Cancer Inhibitors: Isolation, Structure Elucidation, Cytotoxicity, Molecular Docking, Dynamics, and ADME Studies.","description":"The red alga genus <i>Laurencia</i> (Rhodomelaceae) is a prolific source of halogenated secondary metabolites, particularly sesquiterpenes with diverse carbon skeletons and significant biological activities. In this study, four new perforane-type sesquiterpenes (<b>1</b>-<b>4</b>), including two halogenated and two nonhalogenated compounds, were isolated from <i>Laurencia obtusa</i> (Hudson) J. V. Lamouroux. Their chemical structures were elucidated using comprehensive spectroscopic techniques, including 1D- and 2D-NMR, and LC-HRMS. The cytotoxic potential of the isolated compounds was evaluated against human lung adenocarcinoma (A549) cells, revealing notable antiproliferative effects. To explore the molecular basis of their activity, molecular docking and molecular dynamics simulations w","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-19T04:57:21.745Z","creation":"2026-06-19T03:06:55.39Z"},"accession":"S-EPMC12854617","cross_references":{"pubmed":["41626507"],"doi":["10.1021/acsomega.5c08806"]}}