biostudies-literatureDonohue MCADNIAlzheimer's Association; Alzheimer's Drug Discovery FoundationLumosityNIBIB NIH HHSPfizer Inc.NIA NIH HHSCogstateIXICO Ltd.Eisai Inc.GE HealthcareEli Lilly and CompanyCereSpir, Inc.FujirebioTransition TherapeuticsStatewide California Electronic Library ConsortiumMerck & Co., Inc.Novartis Pharmaceuticals CorporationEpstein Family FoundationTakeda Pharmaceutical CompanyFoundation for the National Institutes of HealthBristolMyers Squibb CompanyNorthern California Institute for Research and EducationAraclon BiotechMeso Scale Diagnostics, LLC.ServierSCELCNIH HHSAlbert Einstein College of Medicine and the Foundation for Neurologic DiseasesGHR FoundationYugilbar FoundationNIAElan Pharmaceuticals, Inc.Neurotrack TechnologiesAbbVieBioClinica, Inc.Davis Alzheimer Prevention ProgramCIHRPiramal ImagingAlzheimer's Disease Neuroimaging InitiativeNeuroRx ResearchGenentech, Inc.BiogenJohnson & Johnson Pharmaceutical Research & Development LLC.LundbeckAvid RadiopharmaceuticalsWomen's Hospitale71152https://www.ebi.ac.uk/biostudies/studies/S-EPMC12854935biostudies-literatureUnknown22(2)<h4>Introduction</h4>Sharing clinical research data is essential for advancing Alzheimer's disease (AD) research, yet challenges in accessibility, standardization, documentation, usability, and reproducibility persist.<h4>Methods</h4>We developed R data packages to streamline access to curated datasets from key AD studies. A4LEARN includes data from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's (A4) randomized trial and its companion observational study, the Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN). ADNIMERGE2 contains curated data from the Alzheimer's Disease Neuroimaging Initiative (ADNI), a longitudinal biomarker and imaging study.<h4>Results</h4>These packages bundle data, documentation, and reproducible analysis vignettes into portable, analysis-rAlzheimer's & dementia : the journal of the Alzheimer's AssociationAlzheimer's clinical research data via R packages: The alzverse.PMC12854935U24AG057437U19AG024904Donohue MCGallardo RAlzheimer's Disease Neuroimaging InitiativeLangford OAisen PSJimenez-Maggiora GHussen KfalseAlzheimer's clinical research data via R packages: The alzverse.<h4>Introduction</h4>Sharing clinical research data is essential for advancing Alzheimer's disease (AD) research, yet challenges in accessibility, standardization, documentation, usability, and reproducibility persist.<h4>Methods</h4>We developed R data packages to streamline access to curated datasets from key AD studies. A4LEARN includes data from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's (A4) randomized trial and its companion observational study, the Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN). ADNIMERGE2 contains curated data from the Alzheimer's Disease Neuroimaging Initiative (ADNI), a longitudinal biomarker and imaging study.<h4>Results</h4>These packages bundle data, documentation, and reproducible analysis vignettes into portable, analysis-r2026-01-01T00:00:00Z2026 Feb2026-06-15T08:53:30.467Z2026-06-15T03:11:51.821ZS-EPMC128549354161162410.1002/alz.71152