biostudies-literatureUnknown17Lei J<h4>Introduction</h4>Placental inflammation is a major contributor to preterm birth (PTB), and there are currently few targeted strategies to prevent PTB and its associated adverse neonatal outcomes. Serum amyloid A (SAA), particularly the isoforms SAA1 and SAA2, are well-recognized inflammatory markers, but their functional roles in placental inflammation remain poorly defined.<h4>Methods</h4>Using a translational mouse model of sub-chronic maternal inflammation, we investigated the immune mechanisms and therapeutic potential of siRNA-mediated targeting of Saa2 (siSaa2). Placental expression patterns of SAA2 were examined <i>in vivo</i>, and macrophage responses to extracellular SAA2 were modeled in vitro using RAW264.7 cells to assess downstream P2X7R-dependent signaling and functional oFrontiers in pharmacology1749966https://www.ebi.ac.uk/biostudies/studies/S-EPMC12855142biostudies-literatureTargeting SAA expression via siRNA mitigates preterm birth induced by maternal inflammation.PMC12855142Liu YLiu JLei JLiu AEnninga EALBurd ITownsel CJones-Beatty KfalseTargeting SAA expression via siRNA mitigates preterm birth induced by maternal inflammation.<h4>Introduction</h4>Placental inflammation is a major contributor to preterm birth (PTB), and there are currently few targeted strategies to prevent PTB and its associated adverse neonatal outcomes. Serum amyloid A (SAA), particularly the isoforms SAA1 and SAA2, are well-recognized inflammatory markers, but their functional roles in placental inflammation remain poorly defined.<h4>Methods</h4>Using a translational mouse model of sub-chronic maternal inflammation, we investigated the immune mechanisms and therapeutic potential of siRNA-mediated targeting of Saa2 (siSaa2). Placental expression patterns of SAA2 were examined <i>in vivo</i>, and macrophage responses to extracellular SAA2 were modeled in vitro using RAW264.7 cells to assess downstream P2X7R-dependent signaling and functional o2026-01-01T00:00:00Z20262026-06-19T04:56:48.543Z2026-06-19T03:06:40.655ZS-EPMC128551424162416610.3389/fphar.2026.1749966