{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Audureau E"],"funding":["EMERGEN consortium-ANRS Maladies Infectieuses Emergentes"],"pagination":["605-628"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12855665"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(2)"],"pubmed_abstract":["<h4>Introduction</h4>The clinical presentation of critically ill patients with coronavirus disease 2019 (COVID-19) has evolved significantly with the emergence of the Omicron variant. Current intensive care unit (ICU) admissions involve patients with diverse comorbidities and immune statuses, highlighting the need to redefine homogeneous phenotypic subgroups within this population. This study aimed to characterize distinct clinical phenotypes among critically ill patients with COVID-19 and acute respiratory failure.<h4>Methods</h4>This multicenter prospective substudy of the SEVARVIR cohort included adult patients from 39 French ICUs between December 2021 and October 2024 with acute respiratory failure and infected with the Omicron variant. Clustering analysis was conducted using Kohonen's"],"journal":["Infectious diseases and therapy"],"pubmed_title":["Clinical Phenotypes of Critically Ill Patients with COVID-19 Infected with Omicron: A Nationwide Prospective Cohort Study."],"pmcid":["PMC12855665"],"funding_grant_id":["ANRS0153"],"pubmed_authors":["Maury E","Emery M","Thiery G","Roque-Alfonso AM","Tadie JM","Le Hingrat Q","Megarbane B","Pham T","Mourvillier B","Pawlotsky JM","Tuaillon E","de Prost N","SEVARVIR investigators","Hraeich S","Mekontso Dessap A","Pham TO","Beloncle F","Timsit JF","Damoisel C","Klouche K","Gasperment M","Mayaux J","Levy D","Chevrel G","La Combe B","Clergue C","Henry A","Jandeaux LM","Courdavault Vagh Weinmann L","L'Honneur AS","Moisan A","Kimmoun A","Razazi K","Thibaut V","Gaudry S","Garcia-Sanchez C","Audureau E","Daix T","Preau S","Thibault V","Guigon A","Marot S","Morand-Joubert L","Jochmans S","Guillon A","Charles PE","Haouisee S","Azoulay E","Lunel Fabiani F","Vallet S","Fourati S","Bay P","Tran A","Urbina T","Candace Dossou N","Brechot N","Colson P","Schvoerer E","Pere H","Ait Oufella H","Annane D","Heming N","Thomin J","Dartevel A","Imbert BM","Luyt CE","Meziani F","Voiriot G","Henquell C","Roux D","Hantz S","Boyer A","Plantier JC","De Montmollin N","Larrat S","Delamaire F","Fournier PE","Bocar Fofana D","Uhel F","Tamion F","Du Cheyron D","Handala L","Canet E","Pillet S","Rodriguez C","Brichler S","Burrel S","Flora D","Turpin M","De Rougemont A","Chaix ML","Vieillard-Baron A","Contou D","Chaghouri A","Guignon A","Meireles S","Lepiller Q","Picard L","Pitsch A","Souweine B","Descamps D","Gault E","Hartard C","Fafi-Kremer S","Favory R","Saccheri C","Mourier L","Pene F","Darreau C","Giordanengo V","Piton G","Joseph A","Sabah K","Aubron C","Bellaiche R"],"additional_accession":[]},"is_claimable":false,"name":"Clinical Phenotypes of Critically Ill Patients with COVID-19 Infected with Omicron: A Nationwide Prospective Cohort Study.","description":"<h4>Introduction</h4>The clinical presentation of critically ill patients with coronavirus disease 2019 (COVID-19) has evolved significantly with the emergence of the Omicron variant. Current intensive care unit (ICU) admissions involve patients with diverse comorbidities and immune statuses, highlighting the need to redefine homogeneous phenotypic subgroups within this population. This study aimed to characterize distinct clinical phenotypes among critically ill patients with COVID-19 and acute respiratory failure.<h4>Methods</h4>This multicenter prospective substudy of the SEVARVIR cohort included adult patients from 39 French ICUs between December 2021 and October 2024 with acute respiratory failure and infected with the Omicron variant. Clustering analysis was conducted using Kohonen's","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-06-10T09:00:12.289Z","creation":"2026-06-10T03:12:07.892Z"},"accession":"S-EPMC12855665","cross_references":{"pubmed":["41493514"],"doi":["10.1007/s40121-025-01291-3"]}}