{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["Galluzzo L"],"funding":["Consiglio Nazionale delle Ricerche"],"pubmed_abstract":["<h4>Background</h4>Frailty is recognized as a dynamic and potentially reversible process, but comprehensive studies on its progression/regression are rare.<h4>Objective</h4>To investigate the frequency and characteristics of frailty transitions over time in a representative sample of older Italians.<h4>Design and participants</h4>As secondary analysis of the Italian Longitudinal Study on Aging (ILSA) population-based cohort, we studied all participants (n = 1339; women 47.5 %, age 72.7 ± 5.1) with complete information on changes in frailty status (or death) between consecutive ILSA surveys (T0, T1, T2).<h4>Measurements</h4>Frailty was operationalized according to Fried phenotype, analysing transitions between frailty, or death, during T0-T1, T1-T2 (4-, 5-year length). Transition probabilit"],"journal":["The Journal of frailty & aging"],"pagination":["100117"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12856321"],"repository":["biostudies-literature"],"pubmed_title":["Transitions in frailty states and associated factors: a multistate analysis of the Italian Longitudinal Study on Aging population-based cohort."],"pmcid":["PMC12856321"],"pubmed_authors":["Baldereschi M","Galluzzo L","Di Carlo A","ILSA Working Group","Maggi S","Veronese N","Silano M","Noale M"],"additional_accession":[]},"is_claimable":false,"name":"Transitions in frailty states and associated factors: a multistate analysis of the Italian Longitudinal Study on Aging population-based cohort.","description":"<h4>Background</h4>Frailty is recognized as a dynamic and potentially reversible process, but comprehensive studies on its progression/regression are rare.<h4>Objective</h4>To investigate the frequency and characteristics of frailty transitions over time in a representative sample of older Italians.<h4>Design and participants</h4>As secondary analysis of the Italian Longitudinal Study on Aging (ILSA) population-based cohort, we studied all participants (n = 1339; women 47.5 %, age 72.7 ± 5.1) with complete information on changes in frailty status (or death) between consecutive ILSA surveys (T0, T1, T2).<h4>Measurements</h4>Frailty was operationalized according to Fried phenotype, analysing transitions between frailty, or death, during T0-T1, T1-T2 (4-, 5-year length). Transition probabilit","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-06-09T06:57:55.986Z","creation":"2026-06-09T03:12:01.326Z"},"accession":"S-EPMC12856321","cross_references":{"pubmed":["41546863"],"doi":["10.1016/j.tjfa.2025.100117"]}}