biostudies-literatureUnknown15(1)Galluzzo LConsiglio Nazionale delle Ricerche<h4>Background</h4>Frailty is recognized as a dynamic and potentially reversible process, but comprehensive studies on its progression/regression are rare.<h4>Objective</h4>To investigate the frequency and characteristics of frailty transitions over time in a representative sample of older Italians.<h4>Design and participants</h4>As secondary analysis of the Italian Longitudinal Study on Aging (ILSA) population-based cohort, we studied all participants (n = 1339; women 47.5 %, age 72.7 ± 5.1) with complete information on changes in frailty status (or death) between consecutive ILSA surveys (T0, T1, T2).<h4>Measurements</h4>Frailty was operationalized according to Fried phenotype, analysing transitions between frailty, or death, during T0-T1, T1-T2 (4-, 5-year length). Transition probabilitThe Journal of frailty & aging100117https://www.ebi.ac.uk/biostudies/studies/S-EPMC12856321biostudies-literatureTransitions in frailty states and associated factors: a multistate analysis of the Italian Longitudinal Study on Aging population-based cohort.PMC12856321Baldereschi MGalluzzo LDi Carlo AILSA Working GroupMaggi SVeronese NSilano MNoale MfalseTransitions in frailty states and associated factors: a multistate analysis of the Italian Longitudinal Study on Aging population-based cohort.<h4>Background</h4>Frailty is recognized as a dynamic and potentially reversible process, but comprehensive studies on its progression/regression are rare.<h4>Objective</h4>To investigate the frequency and characteristics of frailty transitions over time in a representative sample of older Italians.<h4>Design and participants</h4>As secondary analysis of the Italian Longitudinal Study on Aging (ILSA) population-based cohort, we studied all participants (n = 1339; women 47.5 %, age 72.7 ± 5.1) with complete information on changes in frailty status (or death) between consecutive ILSA surveys (T0, T1, T2).<h4>Measurements</h4>Frailty was operationalized according to Fried phenotype, analysing transitions between frailty, or death, during T0-T1, T1-T2 (4-, 5-year length). Transition probabilit2026-01-01T00:00:00Z2026 Feb2026-06-09T06:57:55.986Z2026-06-09T03:12:01.326ZS-EPMC128563214154686310.1016/j.tjfa.2025.100117