{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Verrelli D"],"funding":["Institut canadien d&apos;information sur la santé","Canadian Institutes of Health Research"],"pagination":["101207"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12856449"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(2)"],"pubmed_abstract":["<h4>Rationale & objective</h4>During the coronavirus disease 2019 (COVID-19) pandemic, nephrology societies recommended transition from facility-based hemodialysis to home dialysis to minimize risks associated with COVID-19 infection. We compared transition rates from facility-based hemodialysis to home dialysis and rates and reasons for transfers from home dialysis to facility-based hemodialysis before and during the pandemic in Canada.<h4>Study design</h4>Interrupted time-series analysis.<h4>Setting & population</h4>Using administrative data from the Canadian Organ Replacement Register, our cohort included 31,596 and 22,607 adults with any time receiving hemodialysis during the prepandemic and pandemic study periods, respectively.<h4>Exposure</h4>Early pandemic (April 1, 2020-September 30, 2021) versus prepandemic (January 1, 2016-December 31, 2019).<h4>Outcomes</h4>Monthly rates of transitions between facility-based hemodialysis and home dialysis as well as reasons for transfer from home to facility.<h4>Analytical approach</h4>Segmented linear regression and analysis of covariance.<h4>Results</h4>During the early pandemic, transitions to home dialysis increased by 0.60 per 10,000 patients/month (95% CI, 0.08 to 1.11; <i>P</i> = 0.03), beyond the nonsignificant monthly prepandemic trend of 0.02 per 10,000 (95% CI, -0.10 to 0.13; <i>P</i> = 0.80). Monthly transfers from home dialysis to facility-based hemodialysis per 10,000 home dialysis patients also increased during the pandemic (6.91; 95% CI, 3.42 to 10.40; <i>P</i> < 0.001) versus the prepandemic period (-1.78; 95% CI, -4.31 to0.75; <i>P</i> = 0.20). The rate of increase in home-to-facility transfers during the pandemic was not significantly different than facility-to-home transfers (-0.10 transfers/month; 95% CI, -1.51 to 1.31; <i>P</i> = 0.89). More transfers to facility occurred for geographic/resource-related reasons during the pandemic versus prepandemic (5.8% vs 2.7%; <i>P</i> < 0.0001).<h4>Limitations</h4>Inability to analyze change in trends by province and ecological bias.<h4>Conclusions</h4>Transitions from facility-based hemodialysis to home dialysis increased, suggesting kidney care programs in Canada implemented recommendations intended to decrease COVID-19-related risks in this population. Reasons for the observed increase in transfers from home to facility during the pandemic are unclear."],"journal":["Kidney medicine"],"pubmed_title":["Home Dialysis Transitions in Canada During the COVID-19 Pandemic: An Interrupted Time Series Analysis."],"pmcid":["PMC12856449"],"funding_grant_id":["20R26070"],"pubmed_authors":["Verrelli D","Tennankore K","Nickel N","Rigatto C","Brar R","Ferguson T","Harasemiw O","Bohm C","Whitlock R"],"additional_accession":[]},"is_claimable":false,"name":"Home Dialysis Transitions in Canada During the COVID-19 Pandemic: An Interrupted Time Series Analysis.","description":"<h4>Rationale & objective</h4>During the coronavirus disease 2019 (COVID-19) pandemic, nephrology societies recommended transition from facility-based hemodialysis to home dialysis to minimize risks associated with COVID-19 infection. We compared transition rates from facility-based hemodialysis to home dialysis and rates and reasons for transfers from home dialysis to facility-based hemodialysis before and during the pandemic in Canada.<h4>Study design</h4>Interrupted time-series analysis.<h4>Setting & population</h4>Using administrative data from the Canadian Organ Replacement Register, our cohort included 31,596 and 22,607 adults with any time receiving hemodialysis during the prepandemic and pandemic study periods, respectively.<h4>Exposure</h4>Early pandemic (April 1, 2020-September 30, 2021) versus prepandemic (January 1, 2016-December 31, 2019).<h4>Outcomes</h4>Monthly rates of transitions between facility-based hemodialysis and home dialysis as well as reasons for transfer from home to facility.<h4>Analytical approach</h4>Segmented linear regression and analysis of covariance.<h4>Results</h4>During the early pandemic, transitions to home dialysis increased by 0.60 per 10,000 patients/month (95% CI, 0.08 to 1.11; <i>P</i> = 0.03), beyond the nonsignificant monthly prepandemic trend of 0.02 per 10,000 (95% CI, -0.10 to 0.13; <i>P</i> = 0.80). Monthly transfers from home dialysis to facility-based hemodialysis per 10,000 home dialysis patients also increased during the pandemic (6.91; 95% CI, 3.42 to 10.40; <i>P</i> < 0.001) versus the prepandemic period (-1.78; 95% CI, -4.31 to0.75; <i>P</i> = 0.20). The rate of increase in home-to-facility transfers during the pandemic was not significantly different than facility-to-home transfers (-0.10 transfers/month; 95% CI, -1.51 to 1.31; <i>P</i> = 0.89). More transfers to facility occurred for geographic/resource-related reasons during the pandemic versus prepandemic (5.8% vs 2.7%; <i>P</i> < 0.0001).<h4>Limitations</h4>Inability to analyze change in trends by province and ecological bias.<h4>Conclusions</h4>Transitions from facility-based hemodialysis to home dialysis increased, suggesting kidney care programs in Canada implemented recommendations intended to decrease COVID-19-related risks in this population. Reasons for the observed increase in transfers from home to facility during the pandemic are unclear.","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-06-20T05:43:35.957Z","creation":"2026-06-20T03:09:36.23Z"},"accession":"S-EPMC12856449","cross_references":{"pubmed":["41623291"],"doi":["10.1016/j.xkme.2025.101207"]}}