{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Zheng C"],"pubmed_abstract":["Despite the vast diversity of B cell repertoires, serum antibody responses during viral infection often focus on a limited set of epitopesa phenomenon known as immunodominance. This inherent bias establishes a hierarchy of epitope responses, which often facilitates viral immune evasion and presents a major challenge for universal vaccine design. It remains unclear whether serum immunodominance is primarily driven by antigen-intrinsic properties or by the spatial constraints imposed by virion-bound antigen presentation. Here, using Ebola virus glycoprotein (GP) as a model system, we found that trimeric GP elicited varied epitope hierarchies between individual animals during primary immunization. In contrast, multivalent GP presentation on either a vesicular stomatitis virus or ferritin nan"],"journal":["ACS central science"],"pagination":["100-110"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12856675"],"repository":["biostudies-literature"],"pubmed_title":["Oriented Multivalent Display Drives Consistent Serum Immunodominance to the Ebola Virus Glycoprotein."],"pmcid":["PMC12856675"],"pubmed_authors":["Kim PS","Pham D","Pan Z","Rubio AA","Barnes CO","Zheng C","Vasquez S"],"additional_accession":[]},"is_claimable":false,"name":"Oriented Multivalent Display Drives Consistent Serum Immunodominance to the Ebola Virus Glycoprotein.","description":"Despite the vast diversity of B cell repertoires, serum antibody responses during viral infection often focus on a limited set of epitopesa phenomenon known as immunodominance. This inherent bias establishes a hierarchy of epitope responses, which often facilitates viral immune evasion and presents a major challenge for universal vaccine design. It remains unclear whether serum immunodominance is primarily driven by antigen-intrinsic properties or by the spatial constraints imposed by virion-bound antigen presentation. Here, using Ebola virus glycoprotein (GP) as a model system, we found that trimeric GP elicited varied epitope hierarchies between individual animals during primary immunization. In contrast, multivalent GP presentation on either a vesicular stomatitis virus or ferritin nan","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-18T05:52:35.683Z","creation":"2026-06-18T03:07:24.806Z"},"accession":"S-EPMC12856675","cross_references":{"pubmed":["41625225"],"doi":["10.1021/acscentsci.5c01886"]}}