{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hu Z"],"funding":["National Key R&D Program of China","Sun Yat-sen University","Guangzhou Basic and Applied Basic Special Research Project Young PhD \"Qi Hang\" Foundation","Basic and Applied Basic Research Foundation of Guangdong Province","China Postdoctoral Science Foundation","National Natural Science Foundation of China","5010 Clinical Research Program of Sun Yat-sen University"],"pagination":["e71555"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12856699"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(2)"],"pubmed_abstract":["<h4>Background</h4>The optimal therapeutic strategy for patients with T2-3N0-3 M0 or T1N1-3 M0 hypopharyngeal squamous cell carcinoma (HPSCC) and the use of postoperative radiotherapy with or without systemic therapy for patients with T1-2N1M0 HPSCC remain controversial. We aimed to determine whether these additional treatments improve the prognosis in HPSCC.<h4>Methods</h4>We retrospectively analyzed the databases held by the SEER (surveillance, epidemiology, and end results) program and a tertiary referral center in China to evaluate the survival outcomes of surgical intervention for T2-3N0-3 M0 and T1N1-3 M0 HPSCC and of postoperative radiotherapy for T1-2N1M0 disease.<h4>Results</h4>The SEER contained data for 1235 patients with T2-3N0-3 M0 or T1N1-3 M0 HPSCC, of whom 220 underwent sur"],"journal":["Cancer medicine"],"pubmed_title":["Survival Benefit of Adjuvant Radiotherapy After Surgery in Patients With T1-2N1M0 Hypopharyngeal Squamous Cell Carcinoma: A Dual-Cohort Analysis of SEER and Institutional Data."],"pmcid":["PMC12856699"],"funding_grant_id":["2021M703712","2022A1515110147","82403372","2020YFC1316903","2017004","2025A04J4018"],"pubmed_authors":["Wen Y","Ma R","Hu Z","Chen L","Deng J","Lei W","Sun W","Chen S","Wen W"],"additional_accession":[]},"is_claimable":false,"name":"Survival Benefit of Adjuvant Radiotherapy After Surgery in Patients With T1-2N1M0 Hypopharyngeal Squamous Cell Carcinoma: A Dual-Cohort Analysis of SEER and Institutional Data.","description":"<h4>Background</h4>The optimal therapeutic strategy for patients with T2-3N0-3 M0 or T1N1-3 M0 hypopharyngeal squamous cell carcinoma (HPSCC) and the use of postoperative radiotherapy with or without systemic therapy for patients with T1-2N1M0 HPSCC remain controversial. We aimed to determine whether these additional treatments improve the prognosis in HPSCC.<h4>Methods</h4>We retrospectively analyzed the databases held by the SEER (surveillance, epidemiology, and end results) program and a tertiary referral center in China to evaluate the survival outcomes of surgical intervention for T2-3N0-3 M0 and T1N1-3 M0 HPSCC and of postoperative radiotherapy for T1-2N1M0 disease.<h4>Results</h4>The SEER contained data for 1235 patients with T2-3N0-3 M0 or T1N1-3 M0 HPSCC, of whom 220 underwent sur","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-06-14T06:03:13.058Z","creation":"2026-06-14T03:15:20.492Z"},"accession":"S-EPMC12856699","cross_references":{"pubmed":["41614332"],"doi":["10.1002/cam4.71555"]}}