biostudies-literatureHu ZNational Key R&D Program of ChinaSun Yat-sen UniversityGuangzhou Basic and Applied Basic Special Research Project Young PhD "Qi Hang" FoundationBasic and Applied Basic Research Foundation of Guangdong ProvinceChina Postdoctoral Science FoundationNational Natural Science Foundation of China5010 Clinical Research Program of Sun Yat-sen Universitye71555https://www.ebi.ac.uk/biostudies/studies/S-EPMC12856699biostudies-literatureUnknown15(2)<h4>Background</h4>The optimal therapeutic strategy for patients with T2-3N0-3 M0 or T1N1-3 M0 hypopharyngeal squamous cell carcinoma (HPSCC) and the use of postoperative radiotherapy with or without systemic therapy for patients with T1-2N1M0 HPSCC remain controversial. We aimed to determine whether these additional treatments improve the prognosis in HPSCC.<h4>Methods</h4>We retrospectively analyzed the databases held by the SEER (surveillance, epidemiology, and end results) program and a tertiary referral center in China to evaluate the survival outcomes of surgical intervention for T2-3N0-3 M0 and T1N1-3 M0 HPSCC and of postoperative radiotherapy for T1-2N1M0 disease.<h4>Results</h4>The SEER contained data for 1235 patients with T2-3N0-3 M0 or T1N1-3 M0 HPSCC, of whom 220 underwent surCancer medicineSurvival Benefit of Adjuvant Radiotherapy After Surgery in Patients With T1-2N1M0 Hypopharyngeal Squamous Cell Carcinoma: A Dual-Cohort Analysis of SEER and Institutional Data.PMC128566992021M7037122022A1515110147824033722020YFC131690320170042025A04J4018Wen YMa RHu ZChen LDeng JLei WSun WChen SWen WfalseSurvival Benefit of Adjuvant Radiotherapy After Surgery in Patients With T1-2N1M0 Hypopharyngeal Squamous Cell Carcinoma: A Dual-Cohort Analysis of SEER and Institutional Data.<h4>Background</h4>The optimal therapeutic strategy for patients with T2-3N0-3 M0 or T1N1-3 M0 hypopharyngeal squamous cell carcinoma (HPSCC) and the use of postoperative radiotherapy with or without systemic therapy for patients with T1-2N1M0 HPSCC remain controversial. We aimed to determine whether these additional treatments improve the prognosis in HPSCC.<h4>Methods</h4>We retrospectively analyzed the databases held by the SEER (surveillance, epidemiology, and end results) program and a tertiary referral center in China to evaluate the survival outcomes of surgical intervention for T2-3N0-3 M0 and T1N1-3 M0 HPSCC and of postoperative radiotherapy for T1-2N1M0 disease.<h4>Results</h4>The SEER contained data for 1235 patients with T2-3N0-3 M0 or T1N1-3 M0 HPSCC, of whom 220 underwent sur2026-01-01T00:00:00Z2026 Feb2026-06-14T06:03:13.058Z2026-06-14T03:15:20.492ZS-EPMC128566994161433210.1002/cam4.71555