{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Azzi E"],"funding":["Xunta de Galicia","Agencia Estatal de Investigaci?n","European Regional Development Fund"],"pagination":["3801-3810"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12856901"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["148(3)"],"pubmed_abstract":["The conversion of carbon dioxide into value-added products has emerged as an alternative method to achieve net-zero emissions. While technologies that transform CO<sub>2</sub> into fuels and chemical feedstocks have made great strides, the direct use of CO<sub>2</sub> as a C1 synthon for the formation of new carbon-carbon bonds remains a critical challenge. Herein, we present a new catalytic CO<sub>2</sub> activation mode for hydrocarboxylation reactions. Key to this methodology is the formation of a CO<sub>2</sub> carbamate with a phenothiazine catalyst, which sets the required trigonal geometry for the release of CO<sub>2</sub><sup>•-</sup> via photolysis upon absorption of visible light. The polarity-reversed CO<sub>2</sub><sup>•-</sup> is employed in the hydrocarboxylation reactions of alkenes and heterocycles. This protocol is distinguished by its mild reaction conditions, wide substrate scope and broad applicability, even in the context of pharmaceutical cores. Our chemistry can also be utilized for the synthesis of carbon-13 labeled spirolactones using <sup>13</sup>CO<sub>2</sub>. Mechanistic experiments support the photolysis of the CO<sub>2</sub> carbamate as the main productive pathway under our optimized reaction conditions."],"journal":["Journal of the American Chemical Society"],"pubmed_title":["Photolysis of CO<sub>2</sub> Carbamate for Hydrocarboxylation Reactions."],"pmcid":["PMC12856901"],"funding_grant_id":["RYC2022-035515-I","ED431F 2024/027","TED2021-129833A-I00","ED431G 2023/03","PID2020-113067GA-I00","PID2023-151279NB-I00","ED431C 2022/27"],"pubmed_authors":["Scarfiello J","Azzi E","Kolusu SRN","Varela JA","Nappi M","Rodriguez-Martinez M"],"additional_accession":[]},"is_claimable":false,"name":"Photolysis of CO<sub>2</sub> Carbamate for Hydrocarboxylation Reactions.","description":"The conversion of carbon dioxide into value-added products has emerged as an alternative method to achieve net-zero emissions. While technologies that transform CO<sub>2</sub> into fuels and chemical feedstocks have made great strides, the direct use of CO<sub>2</sub> as a C1 synthon for the formation of new carbon-carbon bonds remains a critical challenge. Herein, we present a new catalytic CO<sub>2</sub> activation mode for hydrocarboxylation reactions. Key to this methodology is the formation of a CO<sub>2</sub> carbamate with a phenothiazine catalyst, which sets the required trigonal geometry for the release of CO<sub>2</sub><sup>•-</sup> via photolysis upon absorption of visible light. The polarity-reversed CO<sub>2</sub><sup>•-</sup> is employed in the hydrocarboxylation reactions of alkenes and heterocycles. This protocol is distinguished by its mild reaction conditions, wide substrate scope and broad applicability, even in the context of pharmaceutical cores. Our chemistry can also be utilized for the synthesis of carbon-13 labeled spirolactones using <sup>13</sup>CO<sub>2</sub>. Mechanistic experiments support the photolysis of the CO<sub>2</sub> carbamate as the main productive pathway under our optimized reaction conditions.","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-11T05:41:51.466Z","creation":"2026-06-11T03:08:18.455Z"},"accession":"S-EPMC12856901","cross_references":{"pubmed":["41524413"],"doi":["10.1021/jacs.5c21208"]}}