{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Goga A"],"funding":["Wellcome Trust"],"pagination":["04009"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12856961"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16"],"pubmed_abstract":["<h4>Background</h4>Knowledge gaps persist regarding paediatric COVID-19 clinical presentation, treatment and outcomes in high HIV prevalence settings, with low COVID-19 vaccine coverage.<h4>Methods</h4>An ambi-directional cohort study was conducted in 13 South African public sector hospitals. Hospitalised children with SARS-CoV-2 infection or post-infection syndrome were included. Main outcomes measures included severe disease and primary COVID-19 (hospitalisation for SARS-CoV-2 infection).<h4>Results</h4>There were 2363 SARS-CoV-2 positive children included (March 2020 through May 2023); median age 23.6 months (interquartile range (IQR) = 4.3-98.2 months). Excluding missing values, 1618 (68.9%) children had primary COVID-19; 1121 (69.3%) of these had severe primary COVID-19. In the primar"],"journal":["Journal of global health"],"pubmed_title":["Severe, primary, and incidental COVID-19 in hospitalised children, South Africa: 2020-2023."],"pmcid":["PMC12856961"],"funding_grant_id":["221372/Z/20/Z"],"pubmed_authors":["Ramraj T","Waggie Z","Donald KA","Chetty T","Cloete J","Scott C","Van Zyl R","Chinniah K","Mawela D","Cawood S","Dangor Z","Reubenson G","Morrow BM","Strehlau R","Zuhlke L","Feucht U","Tabane NE","du Plessis NM","Moore DP","Aldersley T","Jeena P","Mchunu N","Zar HJ","Webb K","Archary M","Reddy T","Velaphi S","Goga A"],"additional_accession":[]},"is_claimable":false,"name":"Severe, primary, and incidental COVID-19 in hospitalised children, South Africa: 2020-2023.","description":"<h4>Background</h4>Knowledge gaps persist regarding paediatric COVID-19 clinical presentation, treatment and outcomes in high HIV prevalence settings, with low COVID-19 vaccine coverage.<h4>Methods</h4>An ambi-directional cohort study was conducted in 13 South African public sector hospitals. Hospitalised children with SARS-CoV-2 infection or post-infection syndrome were included. Main outcomes measures included severe disease and primary COVID-19 (hospitalisation for SARS-CoV-2 infection).<h4>Results</h4>There were 2363 SARS-CoV-2 positive children included (March 2020 through May 2023); median age 23.6 months (interquartile range (IQR) = 4.3-98.2 months). Excluding missing values, 1618 (68.9%) children had primary COVID-19; 1121 (69.3%) of these had severe primary COVID-19. In the primar","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-16T06:47:40.725Z","creation":"2026-07-09T10:42:18.313Z"},"accession":"S-EPMC12856961","cross_references":{"pubmed":["41614559"],"doi":["10.7189/jogh.16.04009"]}}