{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Saklatvala JR"],"funding":["UK Medical Research Council Integrative Epidemiology Unit","Estonian Research Council","Innovative Medicines Initiative 2 Joint Undertaking","National Institute for Health Research (NIHR)","NIHR Advanced Fellowship","Wellcome Trust"],"pagination":["14"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12857016"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(1)"],"pubmed_abstract":["<h4>Background</h4>Psoriasis is a common inflammatory skin disease with heterogeneous presentation. Up to 30% of individuals have severe disease with a greater surface area of skin involvement, co-morbidity burden and impact on quality of life. Prognostic biomarkers of psoriasis severity could improve allocation of clinical resources and enable earlier intervention to prevent disease progression, and a genetic biomarker would be cost-effective, stable over time, and unaffected by treatment or comorbidity.<h4>Methods</h4>Psoriasis severity was studied in four European population-based biobanks (Estonian Biobank, HUNT, FinnGen, UK Biobank) and classified based on level of clinical intervention received, with criteria for severe disease including hospitalisation due to psoriasis, use of syste"],"journal":["Genome medicine"],"pubmed_title":["Genetic liability to psoriasis predicts severe disease outcomes."],"pmcid":["PMC12857016"],"funding_grant_id":["PRG1911 and TK (TK214)","220875/Z/20/Z","MC_UU_00011/1, MC_UU_00032/01","821511","NIHR302258"],"pubmed_authors":["Helminen M","Traks T","Estrada K","Harju T","Smith CH","Obeidat ME","Loset M","Arvas M","Vlahiotis A","Gracia-Tabuenca J","Addis L","Bowers N","Perera G","Ngo D","Makela TP","Meretoja T","Burova K","Milani L","Xu F","Tsoi LC","Aberg F","Suominen L","Darne S","Soininen H","Tuomi T","Brumpton B","Miller M","Leinonen R","Miller J","Savukoski S","Ripatti S","Gkini MA","Uimari O","Kytola A","Huertas-Vazquez A","Reilly D","Piltonen T","McKenna K","Farias F","Mishra R","Wong R","Heikinheimo O","Ponnambath N","Linna MM","Chung J","Hochfeld M","Tikkanen J","Kristiansson K","Willberg T","Elenius K","Loukola A","Baudry D","de Rinaldis E","Perola M","Reeve MP","Remes A","Waring J","Koskelainen S","Raghavan N","Longerich S","Hassan S","Aarnisalo A","Palin K","Parkkinen J","Duckworth M","Palin H","Sagoo MK","Weldatsadik R","Betts J","Jacob H","Pelkonen M","Paul D","Kulkarni D","Bizaki-Vallaskangas A","Foerster J","Magi R","Niemi M","Mahil SK","Kahonen M","Balasubramaniam P","Chen H","Tienari P","Verdolini R","Uebe S","Auvinen P","Kuopio T","Hudjashov G","Fahy C","Teng E","Kaarniranta K","Simpson MA","Plenge R","Liu M","Barton A","Pylkas K","Johnson S","Sliz 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T","Hannula-Jouppi K","Gordin D","Siponen M","Joseph T","Lahdenpera S","Carpen O","Hyvarinen K","Li QS","Ding Z","Laisk T","Rose R","Kaiharju E","Kalviainen R","Ruotsalainen S","Ellinghaus D","Kajanne R","McBride S","Domanne E","Kumar J","Brown V","DeSilva B","Chandran V"],"additional_accession":[]},"is_claimable":false,"name":"Genetic liability to psoriasis predicts severe disease outcomes.","description":"<h4>Background</h4>Psoriasis is a common inflammatory skin disease with heterogeneous presentation. Up to 30% of individuals have severe disease with a greater surface area of skin involvement, co-morbidity burden and impact on quality of life. Prognostic biomarkers of psoriasis severity could improve allocation of clinical resources and enable earlier intervention to prevent disease progression, and a genetic biomarker would be cost-effective, stable over time, and unaffected by treatment or comorbidity.<h4>Methods</h4>Psoriasis severity was studied in four European population-based biobanks (Estonian Biobank, HUNT, FinnGen, UK Biobank) and classified based on level of clinical intervention received, with criteria for severe disease including hospitalisation due to psoriasis, use of syste","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-14T06:09:11.86Z","creation":"2026-06-14T03:15:04.849Z"},"accession":"S-EPMC12857016","cross_references":{"pubmed":["41408349"],"doi":["10.1186/s13073-025-01561-2"]}}