{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["60"],"submitter":["Fu M"],"pubmed_abstract":["The treatment of complicated wounds remains unsatisfactory due to the lack of a comprehensive strategy synchronously addressing concomitant disease cure along with favorable wound healing. Herein, a family of thermosensitive citrate-based mussel-inspired bioadhesives (TCMBAs) were developed for the first time by mixing poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)-incorporated and calcium-containing water-soluble injectable citrate-based mussel-inspired bioadhesive prepolymer with FeCl<sub>3</sub> in bicine solution. With a tunable minimum sol-to-gel transition temperature in the range of 28-42 °C, the optimized TCMBAs can be conveniently administrated at room temperature and instantly close wounds at body temperature. TCMBAs exhibit a suite of ideal materi"],"journal":["Bioactive materials"],"pagination":["74-94"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12857384"],"repository":["biostudies-literature"],"pubmed_title":["Thermosensitive citrate-based mussel-inspired attack-defense integrated bioadhesives facilitate complicated wound healing."],"pmcid":["PMC12857384"],"pubmed_authors":["Yang J","Li J","Guo J","Huang Z","Shi Q","Lu Z","Zhou D","Fu M","Zhao Y"],"additional_accession":[]},"is_claimable":false,"name":"Thermosensitive citrate-based mussel-inspired attack-defense integrated bioadhesives facilitate complicated wound healing.","description":"The treatment of complicated wounds remains unsatisfactory due to the lack of a comprehensive strategy synchronously addressing concomitant disease cure along with favorable wound healing. Herein, a family of thermosensitive citrate-based mussel-inspired bioadhesives (TCMBAs) were developed for the first time by mixing poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)-incorporated and calcium-containing water-soluble injectable citrate-based mussel-inspired bioadhesive prepolymer with FeCl<sub>3</sub> in bicine solution. With a tunable minimum sol-to-gel transition temperature in the range of 28-42 °C, the optimized TCMBAs can be conveniently administrated at room temperature and instantly close wounds at body temperature. TCMBAs exhibit a suite of ideal materi","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jun","modification":"2026-06-18T05:48:11.301Z","creation":"2026-06-18T03:07:31.495Z"},"accession":"S-EPMC12857384","cross_references":{"pubmed":["41625490"],"doi":["10.1016/j.bioactmat.2026.01.010"]}}