{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liao G"],"funding":["National Institute of Allergy and Infectious Diseases Division of Intramural Research","NIA NIH HHS","NIAID NIH HHS","NHLBI NIH HHS","National Institutes of Health","Dana Foundation","NIDDK NIH HHS","NIDCD NIH HHS","NINDS NIH HHS","NCI NIH HHS","California Institute for Regenerative Medicine","Gilead Sciences","NIGMS NIH HHS","Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology"],"pagination":["2593-2608.e6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12857809"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["58(10)"],"pubmed_abstract":["Chronic rhinosinusitis (CRS) is a common chronic inflammatory disease of the sinonasal cavity affecting millions worldwide. Its complex pathophysiology remains poorly understood, with emerging evidence implicating interactions between diverse immune and epithelial cells in disease progression. We applied single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics to both dissociated and intact human tissues from individuals with CRS with and without nasal polyps and compared them with controls. We revealed mechanisms of macrophage-eosinophil recruitment, CD4<sup>+</sup> and CD8<sup>+</sup> T cell dysregulation, and mast cell enrichment. We identified key immune-epithelial interactions in tissue remodeling, particularly involving basal progenitor and tuft cells. A distinct basal cell"],"journal":["Immunity"],"pubmed_title":["Multi-scaled transcriptomics of chronically inflamed nasal epithelium reveals immune-epithelial dynamics and tissue remodeling in nasal polyp formation."],"pmcid":["PMC12857809"],"funding_grant_id":["DP2AI171139","U54 AG075931","R01 HL151677","P01 AI177687","P01 CA278732","U19 AI171421","U54 CA260517","U24 CA224331","R01 GM152585","U24CA224331","R01GM152585","R01NS139479","R01AI149672","DP2 AI171139","R01DK138504","R01 DK138504","P01AI177687","U54AG075931","K08 DC019956","R01 NS139479","R01 AI149672","P01CA278732"],"pubmed_authors":["Kim D","Ma Q","Longhi MS","Wang C","Yeh TH","Chang MT","Jiang S","Coller J","Bravo DT","Nolan G","Zarabanda D","Gall PA","Wagh D","Nakayama T","Renteria A","Liao SC","Liao G","Yan CH","Dholakia SS","Nkosi D","Yeung J","Patel ZM","Barouch DH","Nayak JV","Overdevest JB","Yang A","Zhu B","Phillips KM","Lechner M","Chang Y","Hwang PH","Lee IT","Li Z","Borchard NA","Yeo YY","Boussiotis V"],"additional_accession":[]},"is_claimable":false,"name":"Multi-scaled transcriptomics of chronically inflamed nasal epithelium reveals immune-epithelial dynamics and tissue remodeling in nasal polyp formation.","description":"Chronic rhinosinusitis (CRS) is a common chronic inflammatory disease of the sinonasal cavity affecting millions worldwide. Its complex pathophysiology remains poorly understood, with emerging evidence implicating interactions between diverse immune and epithelial cells in disease progression. We applied single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics to both dissociated and intact human tissues from individuals with CRS with and without nasal polyps and compared them with controls. We revealed mechanisms of macrophage-eosinophil recruitment, CD4<sup>+</sup> and CD8<sup>+</sup> T cell dysregulation, and mast cell enrichment. We identified key immune-epithelial interactions in tissue remodeling, particularly involving basal progenitor and tuft cells. A distinct basal cell","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-07-15T13:57:12.512Z","creation":"2026-07-05T03:12:22.198Z"},"accession":"S-EPMC12857809","cross_references":{"pubmed":["40945518"],"doi":["10.1016/j.immuni.2025.08.009"]}}