{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huang D"],"funding":["National Institute of Environmental Health Sciences","University of Science and Technology of China","NIEHS NIH HHS","National Outstanding Youth Foundation of China"],"pagination":["432-441"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12858043"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["While current methods use oxidizable metals as electron donors to effectively reduce Fe<sup>3+</sup>, they suffer from the irreversible oxidation of these metals, ultimately compromising the catalyst's longevity. To address this challenge, we engineered the second coordination shell of a single-atom Fe center by doping boron (B) onto a graphene-based support (Fe<sub>1</sub>/B-graphene) and utilized H<sub>2</sub>O<sub>2</sub> as the electron source for efficient Fe<sup>2+</sup> regeneration. Experimental results, supported by theoretical calculations, revealed that the Fe-O-B motif functions like a micro galvanic cell, with intermediary O atoms facilitating electron transfer between electrodes. Specifically, electrons consumed during H<sub>2</sub>O<sub>2</sub> activation at Fe<sub>1</sub> sites (positive electrode) are replenished by electrons extracted from H<sub>2</sub>O<sub>2</sub> at B atoms (negative electrode), where the activation energy for H<sub>2</sub>O<sub>2</sub> oxidation is significantly lower than that at Fe<sub>1</sub> sites. This study offers inspirational insights into the design of Fenton catalysts through precise regulation of the second coordination shell, demonstrating the potential of tailoring the outer coordination environment of single-atom catalysts to enhance catalytic performance across various reactions."],"journal":["ACS nano"],"pubmed_title":["Manipulating the Second Coordination Shell of Single-Atom Fe for Enhanced Fenton Reaction."],"pmcid":["PMC12858043"],"funding_grant_id":["52100172","P42ES033815","P42 ES033815"],"pubmed_authors":["Liu J","Huang D","Chen J","Rigby K","Niu J","Stavitski E","Wang W","Kim JH","Wang X"],"additional_accession":[]},"is_claimable":false,"name":"Manipulating the Second Coordination Shell of Single-Atom Fe for Enhanced Fenton Reaction.","description":"While current methods use oxidizable metals as electron donors to effectively reduce Fe<sup>3+</sup>, they suffer from the irreversible oxidation of these metals, ultimately compromising the catalyst's longevity. To address this challenge, we engineered the second coordination shell of a single-atom Fe center by doping boron (B) onto a graphene-based support (Fe<sub>1</sub>/B-graphene) and utilized H<sub>2</sub>O<sub>2</sub> as the electron source for efficient Fe<sup>2+</sup> regeneration. Experimental results, supported by theoretical calculations, revealed that the Fe-O-B motif functions like a micro galvanic cell, with intermediary O atoms facilitating electron transfer between electrodes. Specifically, electrons consumed during H<sub>2</sub>O<sub>2</sub> activation at Fe<sub>1</sub> sites (positive electrode) are replenished by electrons extracted from H<sub>2</sub>O<sub>2</sub> at B atoms (negative electrode), where the activation energy for H<sub>2</sub>O<sub>2</sub> oxidation is significantly lower than that at Fe<sub>1</sub> sites. This study offers inspirational insights into the design of Fenton catalysts through precise regulation of the second coordination shell, demonstrating the potential of tailoring the outer coordination environment of single-atom catalysts to enhance catalytic performance across various reactions.","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-14T05:43:24.547Z","creation":"2026-06-14T03:08:55.835Z"},"accession":"S-EPMC12858043","cross_references":{"pubmed":["41457827"],"doi":["10.1021/acsnano.5c13343"]}}