{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kornher K"],"funding":["National Institute of Environmental Health Sciences","NIEHS NIH HHS","University of Michigan Susan B Meister Child Health Evaluation and Research Center"],"pagination":["114526"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12858097"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["265"],"pubmed_abstract":["Per- and polyfluoroalkyl substances (PFAS) and pesticides are widespread environmental contaminants linked to adverse health outcomes; yet, their impact on lung function-individually and as mixtures-remains poorly understood. This study analyzed data from 381 adolescents in a longitudinal cohort in Ecuador, measuring serum levels of three PFAS (perfluorooctanoic acid [PFOA], perfluorooctanesulfonic acid [PFOS], and perfluorononanoic acid [PFNA]) and urinary levels of three pesticides (glyphosate, 2,4-dichlorophenoxyacetic acid [2,4-D], and ethylene thiourea [ETU]). Spirometric lung function was assessed in 2016 and 2022. We evaluated associations between individual chemical levels and lung measures in log-log models estimated via ordinary least squares regression. We used quantile g-comput"],"journal":["International journal of hygiene and environmental health"],"pubmed_title":["Associations of PFAS and pesticides with lung function changes from adolescence to young adulthood in the ESPINA study."],"pmcid":["PMC12858097"],"funding_grant_id":["R21 ES026084","R01 ES025792","U2C ES026560","K01 ES031697","R01 ES030378","P30 ES019776","U2C ES026533"],"pubmed_authors":["Gould CF","Suarez-Torres J","Kornher K","Peterson LA","Barr DB","Manzano JM","Huset CA","Kayser G","Baines K","Martinez D","Suarez-Lopez JR","Tu X"],"additional_accession":[]},"is_claimable":false,"name":"Associations of PFAS and pesticides with lung function changes from adolescence to young adulthood in the ESPINA study.","description":"Per- and polyfluoroalkyl substances (PFAS) and pesticides are widespread environmental contaminants linked to adverse health outcomes; yet, their impact on lung function-individually and as mixtures-remains poorly understood. This study analyzed data from 381 adolescents in a longitudinal cohort in Ecuador, measuring serum levels of three PFAS (perfluorooctanoic acid [PFOA], perfluorooctanesulfonic acid [PFOS], and perfluorononanoic acid [PFNA]) and urinary levels of three pesticides (glyphosate, 2,4-dichlorophenoxyacetic acid [2,4-D], and ethylene thiourea [ETU]). Spirometric lung function was assessed in 2016 and 2022. We evaluated associations between individual chemical levels and lung measures in log-log models estimated via ordinary least squares regression. We used quantile g-comput","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-06-09T07:26:45.994Z","creation":"2026-06-09T03:12:07.76Z"},"accession":"S-EPMC12858097","cross_references":{"pubmed":["39904133"],"doi":["10.1016/j.ijheh.2025.114526"]}}