biostudies-literatureUnknown16(1)de Oliveira Souza NVBee FoundationReliable assessment of prognosis after aneurysmal subarachnoid hemorrhage (SAH) is essential to inform clinical decision-making and prevent premature assumptions of poor outcome. The enhanced SAH (eSAH) score combines three routinely available variables-age, Glasgow Coma Scale (GCS), and subarachnoid hemorrhage blood volume (SAHV)-to provide an objective framework for early outcome stratification. SAHV is estimated using the ABC/2-derived ellipsoid method applied across five major cisternal compartments on non-contrast CT. While the eSAH score has shown promise in initial derivation studies, its external performance and calibration have not yet been validated across diverse healthcare settings. We conducted a retrospective cohort study using consecutive data from two high-volume tertiary cScientific reports4218https://www.ebi.ac.uk/biostudies/studies/S-EPMC12858902biostudies-literatureExternal multicenter validation of the eSAH score for predicting outcomes after subarachnoid hemorrhage.PMC12858902Gutierrez-Aguirre SFMarques IPSharma RNeeraj NAghaebrahim Ade Toledo OFSilva GSde Oliveira Souza NVSauvageau EHanel RAMontserrat LVFreeman WDChaddad Neto FfalseExternal multicenter validation of the eSAH score for predicting outcomes after subarachnoid hemorrhage.Reliable assessment of prognosis after aneurysmal subarachnoid hemorrhage (SAH) is essential to inform clinical decision-making and prevent premature assumptions of poor outcome. The enhanced SAH (eSAH) score combines three routinely available variables-age, Glasgow Coma Scale (GCS), and subarachnoid hemorrhage blood volume (SAHV)-to provide an objective framework for early outcome stratification. SAHV is estimated using the ABC/2-derived ellipsoid method applied across five major cisternal compartments on non-contrast CT. While the eSAH score has shown promise in initial derivation studies, its external performance and calibration have not yet been validated across diverse healthcare settings. We conducted a retrospective cohort study using consecutive data from two high-volume tertiary c2025-01-01T00:00:00Z2025 Dec2026-06-15T06:27:33.807Z2026-06-15T03:08:35.492ZS-EPMC128589024147613010.1038/s41598-025-34326-3