{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Koga Y"],"funding":["Japanese Society of the Promotion of Science"],"pagination":["4124"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12858950"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["The inhibition of fibrosis in filtering blebs is indispensable for lowering intraocular pressure (IOP) after PRESERFLO MicroShunt surgery (PMS). We previously reported the anti-fibrotic effect of OBP-801 (OBP) on a filtering bleb in a rabbit glaucoma filtration surgery model using a 22-gauge cannula. In this study, we investigated the effect of OBP after PMS in rabbit eyes for the development of a new practically applicable anti-fibrotic treatment. This study involved 19 Japanese white rabbits that underwent PMS in the right eye, with those eyes divided into 3 groups: (1) intraoperative subconjunctival injection of 0.02% mitomycin-C (MMC) (n = 6), (2) postoperative instillation of 100 nM OBP eye drops (n = 7), or (3) a balanced salt solution (BSS) control (n = 6). Bleb morphology and IOP w"],"journal":["Scientific reports"],"pubmed_title":["Pluripotent epigenetic regulator OBP-801 attenuates fibrosis and maintains lower intraocular pressure in a rabbit PRESERFLO MicroShunt surgery model."],"pmcid":["PMC12858950"],"funding_grant_id":["20K18352"],"pubmed_authors":["Koga Y","Ueno M","Yoshii K","Mukai A","Hiramoto N","Sotozono C","Yamamoto Y","Murata N","Ikushima T","Mieno H","Urata Y"],"additional_accession":[]},"is_claimable":false,"name":"Pluripotent epigenetic regulator OBP-801 attenuates fibrosis and maintains lower intraocular pressure in a rabbit PRESERFLO MicroShunt surgery model.","description":"The inhibition of fibrosis in filtering blebs is indispensable for lowering intraocular pressure (IOP) after PRESERFLO MicroShunt surgery (PMS). We previously reported the anti-fibrotic effect of OBP-801 (OBP) on a filtering bleb in a rabbit glaucoma filtration surgery model using a 22-gauge cannula. In this study, we investigated the effect of OBP after PMS in rabbit eyes for the development of a new practically applicable anti-fibrotic treatment. This study involved 19 Japanese white rabbits that underwent PMS in the right eye, with those eyes divided into 3 groups: (1) intraoperative subconjunctival injection of 0.02% mitomycin-C (MMC) (n = 6), (2) postoperative instillation of 100 nM OBP eye drops (n = 7), or (3) a balanced salt solution (BSS) control (n = 6). Bleb morphology and IOP w","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-15T04:59:07.73Z","creation":"2026-06-15T03:08:26.818Z"},"accession":"S-EPMC12858950","cross_references":{"pubmed":["41476143"],"doi":["10.1038/s41598-025-34244-4"]}}