biostudies-literatureUnknown30(39)Li C<h4>Background</h4>This case presented the first domestic instance of ablation for persistent left superior vena cava (PLSVC)-associated atrial arrhythmia, utilizing the "Varipulse" pulsed-field ablation system.<h4>Case summary</h4>The computed tomography angiography examination revealed the presence of a PLSVC. During the procedure, left atrial modeling was performed using the CARTO^3D electroanatomical mapping system, and models of the pulmonary veins and PLSVC were manually constructed in conjunction with intracardiac echocardiography. A combined ablation strategy was employed intraoperatively, and after pulsed-field ablation of the earliest activation site in the middle segment of the PLSVC, the patient's rhythm converted to sinus.<h4>Discussion</h4>The "Varipulse" pulsed-field ablation system enables circumferential ablation of atrial fibrillation trigger foci in the PLSVC, achieving rapid, uniform isolation and significantly improving ablation efficiency.<h4>Take-home message</h4>The "Varipulse" pulsed-field ablation system offers a novel technical approach for the precise and safe treatment of atrial arrhythmias associated with PLSVC.JACC. Case reports105981https://www.ebi.ac.uk/biostudies/studies/S-EPMC12859623biostudies-literaturePulsed-Field Ablation Circular Catheter Use in Left Superior Vena Cava-Associated Atrial Arrhythmias.PMC12859623Tao ZLigang DLi CLei HZhicheng HYulong XYan YYu XfalsePulsed-Field Ablation Circular Catheter Use in Left Superior Vena Cava-Associated Atrial Arrhythmias.<h4>Background</h4>This case presented the first domestic instance of ablation for persistent left superior vena cava (PLSVC)-associated atrial arrhythmia, utilizing the "Varipulse" pulsed-field ablation system.<h4>Case summary</h4>The computed tomography angiography examination revealed the presence of a PLSVC. During the procedure, left atrial modeling was performed using the CARTO^3D electroanatomical mapping system, and models of the pulmonary veins and PLSVC were manually constructed in conjunction with intracardiac echocardiography. A combined ablation strategy was employed intraoperatively, and after pulsed-field ablation of the earliest activation site in the middle segment of the PLSVC, the patient's rhythm converted to sinus.<h4>Discussion</h4>The "Varipulse" pulsed-field ablation system enables circumferential ablation of atrial fibrillation trigger foci in the PLSVC, achieving rapid, uniform isolation and significantly improving ablation efficiency.<h4>Take-home message</h4>The "Varipulse" pulsed-field ablation system offers a novel technical approach for the precise and safe treatment of atrial arrhythmias associated with PLSVC.2025-01-01T00:00:00Z2025 Dec2026-06-09T03:08:55.788Z2026-06-09T03:07:36.763ZS-EPMC128596234135001910.1016/j.jaccas.2025.105981