{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["30(39)"],"submitter":["Kino T"],"pubmed_abstract":["<h4>Background</h4>Left ventricular excessive trabeculation (LVET) is associated with malignant ventricular arrhythmias. Polymorphic ventricular tachycardia (PVT) remains particularly challenging, with limited evidence supporting catheter ablation (CA).<h4>Case summary</h4>A 53-year-old woman with LVET presented with drug-refractory PVT triggered by short-coupling ventricular premature contractions. Electroanatomical mapping revealed Purkinje and delayed potentials within the left ventricular septum, localized at the base of a recessed trabecular region. CA targeting these signals successfully eliminated inducible PVT. The patient has remained free from recurrent malignant arrhythmias over 11 years of follow-up.<h4>Discussion</h4>This case highlights the role of the Purkinje fiber network within deep trabeculations in triggering life-threatening arrhythmias. Few reports describe effective CA of PVT in LVET, underscoring the novelty and clinical relevance of this finding.<h4>Take-home message</h4>Deeply recessed Purkinje fibers within LVET can serve as critical triggers for malignant ventricular arrhythmias."],"journal":["JACC. Case reports"],"pagination":["105982"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12859632"],"repository":["biostudies-literature"],"pubmed_title":["Polymorphic Ventricular Tachycardia From Purkinje Network Within Deep Intertrabecular Recesses in Left Ventricular Excessive Trabeculation."],"pmcid":["PMC12859632"],"pubmed_authors":["Yumoto K","Komatsu Y","Nogami A","Kino T","Hanaki Y"],"additional_accession":[]},"is_claimable":false,"name":"Polymorphic Ventricular Tachycardia From Purkinje Network Within Deep Intertrabecular Recesses in Left Ventricular Excessive Trabeculation.","description":"<h4>Background</h4>Left ventricular excessive trabeculation (LVET) is associated with malignant ventricular arrhythmias. Polymorphic ventricular tachycardia (PVT) remains particularly challenging, with limited evidence supporting catheter ablation (CA).<h4>Case summary</h4>A 53-year-old woman with LVET presented with drug-refractory PVT triggered by short-coupling ventricular premature contractions. Electroanatomical mapping revealed Purkinje and delayed potentials within the left ventricular septum, localized at the base of a recessed trabecular region. CA targeting these signals successfully eliminated inducible PVT. The patient has remained free from recurrent malignant arrhythmias over 11 years of follow-up.<h4>Discussion</h4>This case highlights the role of the Purkinje fiber network within deep trabeculations in triggering life-threatening arrhythmias. Few reports describe effective CA of PVT in LVET, underscoring the novelty and clinical relevance of this finding.<h4>Take-home message</h4>Deeply recessed Purkinje fibers within LVET can serve as critical triggers for malignant ventricular arrhythmias.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-14T03:14:01.074Z","creation":"2026-06-14T03:08:58.329Z"},"accession":"S-EPMC12859632","cross_references":{"pubmed":["41350016"],"doi":["10.1016/j.jaccas.2025.105982"]}}