{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gupta S"],"funding":["BLRD VA","NEI NIH HHS"],"pagination":["38"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12859705"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["<h4>Purpose</h4>The inhibitor of differentiation 3 gene therapy via adeno-associated virus 5 (AAV5-Id3) effectively abrogated corneal fibrosis in vivo. This study examined the long-term tolerability and safety of AAV5-Id3 gene therapy for eyes in vivo using a rabbit model.<h4>Methods</h4>Eighteen New Zealand White rabbits, segregated into three groups (naive, AAV5-naked, and AAV5-Id3; n = 6/group), were used. The clinical eye examinations with slit-lamp and multimodal corneal imaging were performed in live rabbits periodically to record the status of ocular and corneal health for up to 7 months. Thereafter, humane euthanasia was performed, and cellular and molecular changes in corneas were studied employing histopathologic, immunofluorescence, and quantitative reverse transcription polymer"],"journal":["Translational vision science & technology"],"pubmed_title":["Long-Term Tolerability and Safety of AAV5-Id3 Gene Therapy to Eyes."],"pmcid":["PMC12859705"],"funding_grant_id":["U01 EY031650","R01 EY030774","IK6 BX005646","I01 BX000357"],"pubmed_authors":["Hesemann NP","Mohan RR","Gupta S","Hofmann AC","Sinha NR","Fraunfelder FW","Sinha PR","Martin LM","Kumar R"],"additional_accession":[]},"is_claimable":false,"name":"Long-Term Tolerability and Safety of AAV5-Id3 Gene Therapy to Eyes.","description":"<h4>Purpose</h4>The inhibitor of differentiation 3 gene therapy via adeno-associated virus 5 (AAV5-Id3) effectively abrogated corneal fibrosis in vivo. This study examined the long-term tolerability and safety of AAV5-Id3 gene therapy for eyes in vivo using a rabbit model.<h4>Methods</h4>Eighteen New Zealand White rabbits, segregated into three groups (naive, AAV5-naked, and AAV5-Id3; n = 6/group), were used. The clinical eye examinations with slit-lamp and multimodal corneal imaging were performed in live rabbits periodically to record the status of ocular and corneal health for up to 7 months. Thereafter, humane euthanasia was performed, and cellular and molecular changes in corneas were studied employing histopathologic, immunofluorescence, and quantitative reverse transcription polymer","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-16T07:22:28.433Z","creation":"2026-06-16T03:09:53.788Z"},"accession":"S-EPMC12859705","cross_references":{"pubmed":["41603714"],"doi":["10.1167/tvst.15.1.38"]}}