{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kostygov AY"],"funding":["Grantová Agentura České Republiky","European Union"],"pagination":["27"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12860189"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["<h4>Background</h4>Trypanosomatids are parasitic flagellates best known for human pathogens causing sleeping sickness, Chagas disease, and leishmaniasis. RNA viruses infecting these protists have recently gained attention for their role in disease severity. While numerous such viruses have been described in Leishmania and several other trypanosomatid genera, none has previously been documented in the iconic genus Trypanosoma.<h4>Results</h4>We report the first discovery and molecular characterization of RNA viruses in trypanosomes, identifying a leishmaniavirus and two narnaviruses in a single strain of Trypanosoma platydactyli, a parasite of the common wall gecko. The leishmaniavirus genome revealed a conserved organization, including a putative ribosomal frameshift site and a hairpin-lik"],"journal":["BMC biology"],"pubmed_title":["The first RNA viruses detected in a trypanosome."],"pmcid":["PMC12860189"],"funding_grant_id":["LERCO CZ.10.03.01/00/22_003/0000003","24-10009S"],"pubmed_authors":["Mendoza-Roldan JA","Kostygov AY","Klocek D","Grybchuk D","Votypka J","Yurchenko V","Lukes J"],"additional_accession":[]},"is_claimable":false,"name":"The first RNA viruses detected in a trypanosome.","description":"<h4>Background</h4>Trypanosomatids are parasitic flagellates best known for human pathogens causing sleeping sickness, Chagas disease, and leishmaniasis. RNA viruses infecting these protists have recently gained attention for their role in disease severity. While numerous such viruses have been described in Leishmania and several other trypanosomatid genera, none has previously been documented in the iconic genus Trypanosoma.<h4>Results</h4>We report the first discovery and molecular characterization of RNA viruses in trypanosomes, identifying a leishmaniavirus and two narnaviruses in a single strain of Trypanosoma platydactyli, a parasite of the common wall gecko. The leishmaniavirus genome revealed a conserved organization, including a putative ribosomal frameshift site and a hairpin-lik","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-11T06:05:05.814Z","creation":"2026-06-11T03:12:23.157Z"},"accession":"S-EPMC12860189","cross_references":{"pubmed":["41618309"],"doi":["10.1186/s12915-025-02497-0"]}}