{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Alvaro BS"],"funding":["Instituto de Salud Carlos III","Conselleria de Cultura, Educación y Ciencia, Generalitat Valenciana"],"pagination":["e202500904"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12860552"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(2)"],"pubmed_abstract":["Cancer caused 9.9 million deaths in 2020, and natural products and/or their structural analogs represent the greatest number of approved small-molecules antitumor agents. Benzopyran and quinoline heterocycles have demonstrated cytotoxic activity against different cancer cell lines. Due to its high therapeutic potential, we report the synthesis of 2-propanamide- and 2-propanamine-dihydrobenzopyrans bearing different amine moieties in the side chain, as well as the 7-carbon prenylated derivatives (analogous to natural polyalthidin). Next, we synthesized the 2-substituted and 2,3-disubstituted quinolines as benzopyran analogs. We evaluated the cytotoxic activity of all nitrogenated derivatives against human cancer cell lines, including A549 (lung cancer), A2058 (melanoma), HepG2 (hepatocellul"],"journal":["ChemMedChem"],"pubmed_title":["Synthesis of Benzopyrans and Quinolines with Nitrogenated Chain and Their Cytotoxicity Against Human Cancer Cell Lines."],"pmcid":["PMC12860552"],"funding_grant_id":["Grant AICO/2021/081","Grant PI21/02045"],"pubmed_authors":["Alvaro BS","Villarroel-Vicente C","Garcia A","Ramos MC","Mackenzie TA","Cortes D","Vila L","Tormo JR","Cabedo N"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis of Benzopyrans and Quinolines with Nitrogenated Chain and Their Cytotoxicity Against Human Cancer Cell Lines.","description":"Cancer caused 9.9 million deaths in 2020, and natural products and/or their structural analogs represent the greatest number of approved small-molecules antitumor agents. Benzopyran and quinoline heterocycles have demonstrated cytotoxic activity against different cancer cell lines. Due to its high therapeutic potential, we report the synthesis of 2-propanamide- and 2-propanamine-dihydrobenzopyrans bearing different amine moieties in the side chain, as well as the 7-carbon prenylated derivatives (analogous to natural polyalthidin). Next, we synthesized the 2-substituted and 2,3-disubstituted quinolines as benzopyran analogs. We evaluated the cytotoxic activity of all nitrogenated derivatives against human cancer cell lines, including A549 (lung cancer), A2058 (melanoma), HepG2 (hepatocellul","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-15T06:30:32.046Z","creation":"2026-06-15T03:08:46.11Z"},"accession":"S-EPMC12860552","cross_references":{"pubmed":["41619306"],"doi":["10.1002/cmdc.202500904"]}}