{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["60"],"submitter":["Xing M"],"pubmed_abstract":["Temporomandibular joint osteoarthritis (TMJ-OA) is a degenerative disease that lacks effective treatment options. The inflammatory microenvironment caused by excessive reactive oxygen species (ROS) in TMJ-OA leads to chondrocyte apoptosis, extracellular matrix (ECM) degradation, and abnormal cartilage metabolism. Herein, we innovatively constructed a manganese-nitrogen-carbon single-atom nanozymes (Mn-NC SAzymes) - chitosan composite hydrogel system. A coordination structure of Mn-N<sub>4</sub> was proposed based on X-ray absorption fine structure spectra. The composite hydrogel achieves an integration of atomic level catalytic design and a localized delivery system. It fully leverages the synergistic dual enzyme-like activities of the Mn - NC SAzyme and the active repair properties of chi"],"journal":["Bioactive materials"],"pagination":["216-242"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12860705"],"repository":["biostudies-literature"],"pubmed_title":["Nanozyme hydrogels remodel pathological microenvironment for temporomandibular joint osteoarthritis therapy via inhibiting MAPK signal pathway."],"pmcid":["PMC12860705"],"pubmed_authors":["Liu X","Zhu M","Qian W","Qiu J","Xing M","Feng J","Cao Y","Chen S","Ye K"],"additional_accession":[]},"is_claimable":false,"name":"Nanozyme hydrogels remodel pathological microenvironment for temporomandibular joint osteoarthritis therapy via inhibiting MAPK signal pathway.","description":"Temporomandibular joint osteoarthritis (TMJ-OA) is a degenerative disease that lacks effective treatment options. The inflammatory microenvironment caused by excessive reactive oxygen species (ROS) in TMJ-OA leads to chondrocyte apoptosis, extracellular matrix (ECM) degradation, and abnormal cartilage metabolism. Herein, we innovatively constructed a manganese-nitrogen-carbon single-atom nanozymes (Mn-NC SAzymes) - chitosan composite hydrogel system. A coordination structure of Mn-N<sub>4</sub> was proposed based on X-ray absorption fine structure spectra. The composite hydrogel achieves an integration of atomic level catalytic design and a localized delivery system. It fully leverages the synergistic dual enzyme-like activities of the Mn - NC SAzyme and the active repair properties of chi","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jun","modification":"2026-06-18T05:52:39.402Z","creation":"2026-06-18T03:07:27.03Z"},"accession":"S-EPMC12860705","cross_references":{"pubmed":["41630826"],"doi":["10.1016/j.bioactmat.2026.01.031"]}}