biostudies-literatureUnknown5(2)Al Zein M<h4>Background</h4>Mitral annular calcification (MAC) is a progressive degenerative condition characterized by calcium deposition on the mitral apparatus, and is associated with adverse outcomes. Data on mitral regurgitation (MR) caused by MAC are limited.<h4>Objectives</h4>This study evaluates the prognostic significance of left atrial strain (LAS) in patients with severe MR due to MAC.<h4>Methods</h4>We conducted a retrospective, single-center cohort study including patients with isolated severe MR due to MAC. Clinical data were retrieved, and the primary outcome was all-cause mortality. Echocardiographic parameters including LAS were recorded. The cohort was stratified by the median reservoir LAS (LASr).<h4>Results</h4>Between January 2010 and August 2023, 128 patients with isolated sevJACC. Advances102568https://www.ebi.ac.uk/biostudies/studies/S-EPMC12860982biostudies-literatureImpact of Left Atrial Strain on Severe Mitral Regurgitation Due to Mitral Annular Calcification.PMC12860982Okushi YUnai SPettersson GBXu BAl Zein MGrimm RAGriffin BPGillinov AMfalseImpact of Left Atrial Strain on Severe Mitral Regurgitation Due to Mitral Annular Calcification.<h4>Background</h4>Mitral annular calcification (MAC) is a progressive degenerative condition characterized by calcium deposition on the mitral apparatus, and is associated with adverse outcomes. Data on mitral regurgitation (MR) caused by MAC are limited.<h4>Objectives</h4>This study evaluates the prognostic significance of left atrial strain (LAS) in patients with severe MR due to MAC.<h4>Methods</h4>We conducted a retrospective, single-center cohort study including patients with isolated severe MR due to MAC. Clinical data were retrieved, and the primary outcome was all-cause mortality. Echocardiographic parameters including LAS were recorded. The cohort was stratified by the median reservoir LAS (LASr).<h4>Results</h4>Between January 2010 and August 2023, 128 patients with isolated sev2026-01-01T00:00:00Z2026 Jan2026-06-18T05:51:45.326Z2026-06-18T03:07:12.086ZS-EPMC128609824157659810.1016/j.jacadv.2025.102568