{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lee JH"],"funding":["NINDS NIH HHS"],"pagination":["164-172"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12862983"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["644(8075)"],"pubmed_abstract":["Self-recognition is a fundamental cellular process across evolution and forms the basis of neuronal self-avoidance<sup>1-4</sup>. Clustered protocadherin (cPcdh) proteins, which comprise a large family of isoform-specific homophilic recognition molecules, have a pivotal role in the neuronal self-avoidance that is required for mammalian brain development<sup>5-7</sup>. The probabilistic expression of different cPcdh isoforms confers unique identities on neurons and forms the basis for neuronal processes to discriminate between self and non-self<sup>5,6,8</sup>. Whether this self-recognition mechanism also exists in astrocytes remains unknown. Here we report that γC3, a specific isoform in the Pcdhγ family, is enriched in human and mouse astrocytes. Using genetic manipulation, we demonstrate"],"journal":["Nature"],"pubmed_title":["Astrocyte morphogenesis requires self-recognition."],"pmcid":["PMC12862983"],"funding_grant_id":["R35 NS111583","T32 NS048004"],"pubmed_authors":["Goodman KM","Sergeeva AP","Mannepalli S","Xu R","Weiner JA","Khakh BS","Zipursky SL","Bahna F","Shapiro L","Ahlsen G","Honig B","Lee JH"],"additional_accession":[]},"is_claimable":false,"name":"Astrocyte morphogenesis requires self-recognition.","description":"Self-recognition is a fundamental cellular process across evolution and forms the basis of neuronal self-avoidance<sup>1-4</sup>. Clustered protocadherin (cPcdh) proteins, which comprise a large family of isoform-specific homophilic recognition molecules, have a pivotal role in the neuronal self-avoidance that is required for mammalian brain development<sup>5-7</sup>. The probabilistic expression of different cPcdh isoforms confers unique identities on neurons and forms the basis for neuronal processes to discriminate between self and non-self<sup>5,6,8</sup>. Whether this self-recognition mechanism also exists in astrocytes remains unknown. Here we report that γC3, a specific isoform in the Pcdhγ family, is enriched in human and mouse astrocytes. Using genetic manipulation, we demonstrate","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-07-14T17:26:45.046Z","creation":"2026-06-21T03:12:34.77Z"},"accession":"S-EPMC12862983","cross_references":{"pubmed":["40437095"],"doi":["10.1038/s41586-025-09013-y"]}}