biostudies-literatureGilley SPEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNICHD NIH HHSU.S. Department of AgricultureGates FoundationUSDA Agricultural Research Service101279https://www.ebi.ac.uk/biostudies/studies/S-EPMC12863136biostudies-literatureUnknown156(2)<h4>Background</h4>Maternal selenium deficiency is hypothesized to contribute to risk of adverse outcomes including low birth weight and prematurity, possibly through its role as an antioxidant and/or in thyroid hormone function.<h4>Objectives</h4>We assessed relationships between maternal selenium concentrations during pregnancy with offspring outcomes including birth measurements, low birth weight (<2500 g), prematurity (<37 wk), and small for gestational age (birth weight <10th percentile for gestational age).<h4>Methods</h4>This was a secondary analysis of the Women First Trial (NCT01883193), a randomized controlled study investigating the effect of small-quantity lipid-based nutrition supplement (sqLNS) with 130 μg selenium on fetal growth. sqLNS was started ≥3 mo prior to conception,The Journal of nutritionA Multicountry Analysis of Maternal Selenium Status in Pregnancy and Lactation and Infant Birth Outcomes: Findings from the Women First Maternal Preconception Study.PMC12863136U10 HD076474Garces AWestcott JLGoldenberg RLGoudar SMcClure EMLong JMShankar KSaleem SGilley SPHambidge KMWomen First Trial GroupSomannavar MSKrebs NFDas AAli SAKemp JFDerman Lester Figueroa RJfalseA Multicountry Analysis of Maternal Selenium Status in Pregnancy and Lactation and Infant Birth Outcomes: Findings from the Women First Maternal Preconception Study.<h4>Background</h4>Maternal selenium deficiency is hypothesized to contribute to risk of adverse outcomes including low birth weight and prematurity, possibly through its role as an antioxidant and/or in thyroid hormone function.<h4>Objectives</h4>We assessed relationships between maternal selenium concentrations during pregnancy with offspring outcomes including birth measurements, low birth weight (<2500 g), prematurity (<37 wk), and small for gestational age (birth weight <10th percentile for gestational age).<h4>Methods</h4>This was a secondary analysis of the Women First Trial (NCT01883193), a randomized controlled study investigating the effect of small-quantity lipid-based nutrition supplement (sqLNS) with 130 μg selenium on fetal growth. sqLNS was started ≥3 mo prior to conception,2026-01-01T00:00:00Z2026 Feb2026-07-16T03:11:39.218Z2026-07-09T10:30:52.122ZS-EPMC128631364146127310.1016/j.tjnut.2025.101279