{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu Y"],"funding":["Johns Hopkins University","National Institutes of Health","NIH HHS","NIGMS NIH HHS"],"pagination":["jcs264128"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12863306"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["139(1)"],"pubmed_abstract":["Cell shape regulation is important for many biological processes. Some cell shape-regulating proteins harbor mechanoresponsive properties that enable them to sense and respond to mechanical cues. In Dictyostelium discoideum, mechanoresponsive network proteins formed by proteins such as myosin II, cortexillin I and IQGAP1 assemble in the cytoplasm into macromolecular complexes, which we term contractility kits (CKs). In our previous studies, we identified the RNA-binding protein RNP1A as a genetic interactor with the cytoskeletal machinery of the cell and as a biochemical interactor of cortexillin I, using in vivo fluorescence cross-correlation spectroscopy. In this study, we show that Dictyostelium rnp1A knockdown cells have reduced cell proliferation, reduced adhesion, defective cytokines"],"journal":["Journal of cell science"],"pubmed_title":["The RNA-binding protein RNP1A is essential and interacts with contractility kit proteins to facilitate cell mechanics."],"pmcid":["PMC12863306"],"funding_grant_id":["R01 GM066817","GM66817"],"pubmed_authors":["Liu Y","Robinson DN","Alotaibi A","Nguyen LTS","Jacob MAC","Leng J"],"additional_accession":[]},"is_claimable":false,"name":"The RNA-binding protein RNP1A is essential and interacts with contractility kit proteins to facilitate cell mechanics.","description":"Cell shape regulation is important for many biological processes. Some cell shape-regulating proteins harbor mechanoresponsive properties that enable them to sense and respond to mechanical cues. In Dictyostelium discoideum, mechanoresponsive network proteins formed by proteins such as myosin II, cortexillin I and IQGAP1 assemble in the cytoplasm into macromolecular complexes, which we term contractility kits (CKs). In our previous studies, we identified the RNA-binding protein RNP1A as a genetic interactor with the cytoskeletal machinery of the cell and as a biochemical interactor of cortexillin I, using in vivo fluorescence cross-correlation spectroscopy. In this study, we show that Dictyostelium rnp1A knockdown cells have reduced cell proliferation, reduced adhesion, defective cytokines","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-14T20:54:46.419Z","creation":"2026-06-24T03:04:22.037Z"},"accession":"S-EPMC12863306","cross_references":{"pubmed":["41332277"],"doi":["10.1242/jcs.264128"]}}