{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["54(1)"],"submitter":["Millet Pascual-Leone B"],"funding":["Charité - Universitätsmedizin Berlin"],"pubmed_abstract":["<h4>Purpose</h4>Diabetes mellitus (DM) is a relevant risk factor for enhanced susceptibility to and adverse outcomes in infections, including community-acquired pneumonia (CAP). We aimed to characterise clinical outcomes, inflammatory and organ failure markers and microbial etiologies in diabetic (DM+) versus non-diabetic (DM-) patients in a European CAP cohort.<h4>Methods</h4>Comparative analyses using data from the CAPNETZ multicenter, prospective, observational study including 13,611 patients with CAP enrolled between 2002-2022, with and without a history of DM, were conducted.<h4>Results</h4>Seventeen percent (2310/13,611) had a history of DM (DM+). Compared to DM- patients, DM+ patients had a higher 180 days mortality rate following CAP (13% (292/2310) vs. 7% (766/11,301), p < 0.0001)"],"journal":["Infection"],"pagination":["275-285"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12864321"],"repository":["biostudies-literature"],"pubmed_title":["Community-acquired pneumonia in diabetic patients is characterised by a distinct pathogen spectrum and enhanced inflammation: results from CAPNETZ, a prospective observational cohort study."],"pmcid":["PMC12864321"],"pubmed_authors":["Rohde G","Krishnamoorthy G","Unnewehr M","Vestergaard Jensen A","Thibeault C","Hillus D","Moeser A","Schubert L","Opitz B","Fiocca Vernengo F","Bauer W","Hering I","Benke D","Paul G","Rupp J","CAPNETZ-study group","Stolz D","Breitschwerdt S","Pletz MW","Suttorp N","Seeger A","Wirth B","Prasse A","Klopp N","Schleenvoigt BT","Drick N","Wernicke C","Ronczka J","Stoppe YM","Stenger S","Pink I","Franzen K","Lim R","Diehl-Wiesenecker EC","Adaskina N","Waldeck F","Kodde C","Heigener D","Albrich W","Panning M","Burgmann H","Illig T","Schmager S","Kolditz M","Ayoub M","Kohlhaufl J","Fuhner T","Neurohr C","Witzenrath M","Galtung N","Wheeler J","Schulte-Hubbert B","Traby L","Steinberg T","Wallner M","Voit F","Gebel B","Erber J","Dromann D","Grunewaldt A","Fahndrich S","Boesecke C","Kroner W","Kremling J","Barten-Neiner G","Rassouli F","Eberhardt F","Parschke P","Schneider J","Millet Pascual-Leone B","Essig A","Schaaf B","Kading N","Hoeper M","Unruh O","Boutin S","Sander LE","Fuchs A"],"additional_accession":[]},"is_claimable":false,"name":"Community-acquired pneumonia in diabetic patients is characterised by a distinct pathogen spectrum and enhanced inflammation: results from CAPNETZ, a prospective observational cohort study.","description":"<h4>Purpose</h4>Diabetes mellitus (DM) is a relevant risk factor for enhanced susceptibility to and adverse outcomes in infections, including community-acquired pneumonia (CAP). We aimed to characterise clinical outcomes, inflammatory and organ failure markers and microbial etiologies in diabetic (DM+) versus non-diabetic (DM-) patients in a European CAP cohort.<h4>Methods</h4>Comparative analyses using data from the CAPNETZ multicenter, prospective, observational study including 13,611 patients with CAP enrolled between 2002-2022, with and without a history of DM, were conducted.<h4>Results</h4>Seventeen percent (2310/13,611) had a history of DM (DM+). Compared to DM- patients, DM+ patients had a higher 180 days mortality rate following CAP (13% (292/2310) vs. 7% (766/11,301), p < 0.0001)","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-15T00:50:05.921Z","creation":"2026-06-27T03:05:41.981Z"},"accession":"S-EPMC12864321","cross_references":{"pubmed":["41077620"],"doi":["10.1007/s15010-025-02659-w"]}}