biostudies-literatureUnknown54(1)Millet Pascual-Leone BCharité - Universitätsmedizin Berlin<h4>Purpose</h4>Diabetes mellitus (DM) is a relevant risk factor for enhanced susceptibility to and adverse outcomes in infections, including community-acquired pneumonia (CAP). We aimed to characterise clinical outcomes, inflammatory and organ failure markers and microbial etiologies in diabetic (DM+) versus non-diabetic (DM-) patients in a European CAP cohort.<h4>Methods</h4>Comparative analyses using data from the CAPNETZ multicenter, prospective, observational study including 13,611 patients with CAP enrolled between 2002-2022, with and without a history of DM, were conducted.<h4>Results</h4>Seventeen percent (2310/13,611) had a history of DM (DM+). Compared to DM- patients, DM+ patients had a higher 180 days mortality rate following CAP (13% (292/2310) vs. 7% (766/11,301), p < 0.0001)Infection275-285https://www.ebi.ac.uk/biostudies/studies/S-EPMC12864321biostudies-literatureCommunity-acquired pneumonia in diabetic patients is characterised by a distinct pathogen spectrum and enhanced inflammation: results from CAPNETZ, a prospective observational cohort study.PMC12864321Rohde GKrishnamoorthy GUnnewehr MVestergaard Jensen AThibeault CHillus DMoeser ASchubert LOpitz BFiocca Vernengo FBauer WHering IBenke DPaul GRupp JCAPNETZ-study groupStolz DBreitschwerdt SPletz MWSuttorp NSeeger AWirth BPrasse AKlopp NSchleenvoigt BTDrick NWernicke CRonczka JStoppe YMStenger SPink IFranzen KLim RDiehl-Wiesenecker ECAdaskina NWaldeck FKodde CHeigener DAlbrich WPanning MBurgmann HIllig TSchmager SKolditz MAyoub MKohlhaufl JFuhner TNeurohr CWitzenrath MGaltung NWheeler JSchulte-Hubbert BTraby LSteinberg TWallner MVoit FGebel BErber JDromann DGrunewaldt AFahndrich SBoesecke CKroner WKremling JBarten-Neiner GRassouli FEberhardt FParschke PSchneider JMillet Pascual-Leone BEssig ASchaaf BKading NHoeper MUnruh OBoutin SSander LEFuchs AfalseCommunity-acquired pneumonia in diabetic patients is characterised by a distinct pathogen spectrum and enhanced inflammation: results from CAPNETZ, a prospective observational cohort study.<h4>Purpose</h4>Diabetes mellitus (DM) is a relevant risk factor for enhanced susceptibility to and adverse outcomes in infections, including community-acquired pneumonia (CAP). We aimed to characterise clinical outcomes, inflammatory and organ failure markers and microbial etiologies in diabetic (DM+) versus non-diabetic (DM-) patients in a European CAP cohort.<h4>Methods</h4>Comparative analyses using data from the CAPNETZ multicenter, prospective, observational study including 13,611 patients with CAP enrolled between 2002-2022, with and without a history of DM, were conducted.<h4>Results</h4>Seventeen percent (2310/13,611) had a history of DM (DM+). Compared to DM- patients, DM+ patients had a higher 180 days mortality rate following CAP (13% (292/2310) vs. 7% (766/11,301), p < 0.0001)2026-01-01T00:00:00Z2026 Feb2026-07-15T00:50:05.921Z2026-06-27T03:05:41.981ZS-EPMC128643214107762010.1007/s15010-025-02659-w