{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yesharim Y"],"funding":["European Research Council","European Molecular Biology Laboratory","Israel Science Foundation","Israel Science Foundation (ISF)","EIPOD-LinC"],"pagination":["749-788"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12864844"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["45(3)"],"pubmed_abstract":["Cell fate decisions require tight regulation of gene expression. In planarians, highly regenerative flatworms, the mRNA modification N⁶-methyladenosine (m⁶A) modulates progenitor production and fate. However, the mechanisms governing m⁶A deposition in the planarian transcriptome, and the role of their expanded family of YTHDF m⁶A reader proteins in orchestrating biological functions, remain unclear. Here, we generated the first single-nucleotide resolution map of m⁶A in planarians, and revealed that simple sequence rules guide m⁶A deposition, facilitating the flexible evolutionary gain and loss of these marks. Functional analyses of the five YTHDF planarian m⁶A readers revealed that while individual reader expression is dispensable, together, the planarian YTHDF proteins regulate the produ"],"journal":["The EMBO journal"],"pubmed_title":["Single-nucleotide m⁶A mapping uncovers redundant YTHDF function in planarian progenitor fate selection."],"pmcid":["PMC12864844"],"funding_grant_id":["543165","2039/18","913/21","853640"],"pubmed_authors":["Schwartz S","Barboy-Smoliarenko J","Shachar R","Yesharim Y","Wurtzel O","Cherian PV","Vu HT","Shwarzbard O","Palavalli A"],"additional_accession":[]},"is_claimable":false,"name":"Single-nucleotide m⁶A mapping uncovers redundant YTHDF function in planarian progenitor fate selection.","description":"Cell fate decisions require tight regulation of gene expression. In planarians, highly regenerative flatworms, the mRNA modification N⁶-methyladenosine (m⁶A) modulates progenitor production and fate. However, the mechanisms governing m⁶A deposition in the planarian transcriptome, and the role of their expanded family of YTHDF m⁶A reader proteins in orchestrating biological functions, remain unclear. Here, we generated the first single-nucleotide resolution map of m⁶A in planarians, and revealed that simple sequence rules guide m⁶A deposition, facilitating the flexible evolutionary gain and loss of these marks. Functional analyses of the five YTHDF planarian m⁶A readers revealed that while individual reader expression is dispensable, together, the planarian YTHDF proteins regulate the produ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-15T12:03:00.935Z","creation":"2026-07-04T03:12:36.96Z"},"accession":"S-EPMC12864844","cross_references":{"pubmed":["41484363"],"doi":["10.1038/s44318-025-00662-3"]}}