{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Burgueno JF"],"funding":["National Institute of Diabetes and Digestive and Kidney Diseases","NIDDK NIH HHS","Cedars-Sinai Medical Center"],"pagination":["101694"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12865638"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(4)"],"pubmed_abstract":["<h4>Background & aims</h4>Duodenal adenomas have malignant potential, yet the drivers of duodenal tumorigenesis remain unclear. Duodenal adenomas robustly develop in villin- Toll-like receptor 4 (TLR4) mice, a transgenic mouse model of increased innate immune signaling in the intestinal epithelium. Here, we sought to test the contributions of the microbiota and bile acids to duodenal adenoma development.<h4>Methods</h4>Duodenal tissue was analyzed for proliferation rate and histology in villin-TLR4 vs wild-type mice. Mice were rederived into germ-free conditions and administered a diet containing the bile acid sequestering resin cholestyramine or treated with the NADPH oxidase inhibitor apocynin. Chemokine expression and myeloid cell recruitment were measured. Findings from mouse studies w"],"journal":["Cellular and molecular gastroenterology and hepatology"],"pubmed_title":["Local Interactions Between Innate Immune Signaling, Microbiota, and Bile Acids Drive the Development of Duodenal Adenomas."],"pmcid":["PMC12865638"],"funding_grant_id":["R01DK099076","R01 DK099076"],"pubmed_authors":["Brito N","Santander AM","Fernandez I","Gonzalez EE","Ban Y","Jacobsen GE","Wilson L","Barnes S","Pignac-Kobinger J","Burgueno JF","Wang L","Hazime H","Sundrud MS","Fritsch J","Cickovski T","Gao Z","Abreu MT","Dione HD"],"additional_accession":[]},"is_claimable":false,"name":"Local Interactions Between Innate Immune Signaling, Microbiota, and Bile Acids Drive the Development of Duodenal Adenomas.","description":"<h4>Background & aims</h4>Duodenal adenomas have malignant potential, yet the drivers of duodenal tumorigenesis remain unclear. Duodenal adenomas robustly develop in villin- Toll-like receptor 4 (TLR4) mice, a transgenic mouse model of increased innate immune signaling in the intestinal epithelium. Here, we sought to test the contributions of the microbiota and bile acids to duodenal adenoma development.<h4>Methods</h4>Duodenal tissue was analyzed for proliferation rate and histology in villin-TLR4 vs wild-type mice. Mice were rederived into germ-free conditions and administered a diet containing the bile acid sequestering resin cholestyramine or treated with the NADPH oxidase inhibitor apocynin. Chemokine expression and myeloid cell recruitment were measured. Findings from mouse studies w","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-07-05T03:13:14.634Z","creation":"2026-07-05T03:11:42.54Z"},"accession":"S-EPMC12865638","cross_references":{"pubmed":["41344439"],"doi":["10.1016/j.jcmgh.2025.101694"]}}