{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(8)"],"submitter":["Zeng Y"],"pubmed_abstract":["Preparation and characterization of a series of oligo(ethylene glycol)methylether functionalized alkynyl gold(i) complexes capped with AuPPh<sub>3</sub> (1a-1d) or dppfAu<sub>2</sub> (dppf, 1,1'-<i>bis</i>(diphenyphosphino)ferrocene) (2a-2d) have been accomplished. The structures of 1b and 1c were established by X-ray crystallography. Their <i>in vitro</i> antitumor activities were measured by the CCK8 method against A549 and HeLa cells. The studies indicated that the cytotoxic activity <i>in vitro</i> was fine-tuned by modification of both the gold(i) centers and the oligo(ethylene glycol)methylether ancillary ligands. Compared to the dppfAu<sub>2</sub> series, the AuPPh<sub>3</sub> series showed better cytotoxicity. Especially, complex 4-(OCH<sub>2</sub>CH<sub>2</sub>OCH<sub>2</sub>CH<su"],"journal":["RSC advances"],"pagination":["7092-7096"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12865784"],"repository":["biostudies-literature"],"pubmed_title":["Synthesis and antitumor activity of mono and digold(i) alkynyl complexes with oligo(ethylene glycol)methylether."],"pmcid":["PMC12865784"],"pubmed_authors":["Chen QM","Zhou P","Zhang JF","Ren WX","Mou X","Zeng Y","Zheng F","Wu XH","Jin L"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis and antitumor activity of mono and digold(i) alkynyl complexes with oligo(ethylene glycol)methylether.","description":"Preparation and characterization of a series of oligo(ethylene glycol)methylether functionalized alkynyl gold(i) complexes capped with AuPPh<sub>3</sub> (1a-1d) or dppfAu<sub>2</sub> (dppf, 1,1'-<i>bis</i>(diphenyphosphino)ferrocene) (2a-2d) have been accomplished. The structures of 1b and 1c were established by X-ray crystallography. Their <i>in vitro</i> antitumor activities were measured by the CCK8 method against A549 and HeLa cells. The studies indicated that the cytotoxic activity <i>in vitro</i> was fine-tuned by modification of both the gold(i) centers and the oligo(ethylene glycol)methylether ancillary ligands. Compared to the dppfAu<sub>2</sub> series, the AuPPh<sub>3</sub> series showed better cytotoxicity. Especially, complex 4-(OCH<sub>2</sub>CH<sub>2</sub>OCH<sub>2</sub>CH<su","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-15T06:43:09.932Z","creation":"2026-06-30T03:21:57.987Z"},"accession":"S-EPMC12865784","cross_references":{"pubmed":["41641232"],"doi":["10.1039/d5ra08951d"]}}